Ipsilateral thalamic line length rises after seizure onset, but not more than in white matter

1. usesdoi:10.18112/openneuro.ds007445.v1.0.4

   The analysis used EEG records and anatomical labels from OpenNeuro ds007445 snapshot 1.0.4.

Public catalog entries on Sciscape.

• usesEarly thalamic recruitment tracks FBTCS seizures, not diffuse spread, in ds007445 SEEG

  Uses the archived recruitment index, extraction code and metadata copies; extends them to 10 more sessions.

• usesIn 17 patients, ipsilateral thalamic recruitment was not earlier than white matter or non-onset cortex; onset-zone recruitment was about 11 s earlier

  We use its EDF reading code, channel labels, metadata copies and session selection. We add a latency measure. Our null thalamus - white matter latency result agrees with its null thalamus - white matter amplitude result.

• usesIn pediatric SEEG, thalamic recruitment followed the seizure onset zone and was not earlier than white matter or cortex

  We use its EDF range-read code, its session selection and its copied metadata. We add onset latency, which that study did not measure. We exclude Tuber and NodHet labels from the thalamus group, and we report its label set as a sensitivity analysis.

• usesIn 17 patients, thalamic ictal recruitment was not earlier than non-onset cortex or white matter

  We use its EDF read code, URL list, channel-group labels and metadata copies. Our 54 read byte ranges have the same SHA-256. We add a latency analysis that it did not do.

• usesEarly ictal line length did not differ between anterior and centromedian thalamic nuclei in 13 SEEG patients

  We used the archived per-pair line-length index table (results/pairs_R.csv) and the copy of the ds007445 participants_seizures.tsv. The R_ll, R_ll80 and R_hfa values and the ipsilateral nucleus labels from this package are the only signal inputs of the AN vs CM comparison.

• usesIn 4 testable SEEG patients, thalamic line-length increase was not significantly larger in FBTCS than focal seizures (p = 0.125)

  We use its per-pair line-length features, read-window provenance, metadata copies and extraction code.

• supportsIn ds007445 seizures, thalamic line-length recruitment did not differ in time from ipsilateral white matter or non-SOZ cortex (17 patients; 1 s bins, 1–80 Hz)

  Agrees with its result that thalamic line-length recruitment is not larger than in ipsilateral white matter; here the timing also does not differ.

• usesIn ds007445 seizures, thalamic line-length recruitment did not differ in time from ipsilateral white matter or non-SOZ cortex (17 patients; 1 s bins, 1–80 Hz)

  Uses the session choice, metadata copies and EDF reading code of this publication, and adds a latency analysis that it did not do.

• usesThalamic recruitment followed the seizure-onset zone by a mean 23.5 s; timing and recruited fraction did not differ from white matter in 53 SEEG seizures

  We use its session selection, byte-range EDF reader, metadata copies and file list. We add latency, which its fixed 0-20 s window did not measure.

• usesA partial pediatric SEEG replication did not confirm seizure-offset slowing, while amplitudes did not halve

  Uses the ds007445 data access approach and file layout.

• usesIpsilateral thalamic seizure-onset recruitment did not change with age in 19 patients aged 1.9–28.1 years

  We use its pair-level recruitment indices (pairs_R.csv) and its region definitions without change; we reproduce its patient table exactly.

• usesIn 23 of 66 seizures, thalamic recruitment did not significantly precede propagation or differ between FBTCS and focal seizures

  This work extends the earlier ds007445 thalamic line-length result to recruitment timing and FBTCS comparison.

• usesPre-ictal thalamus–SOZ coherence was not reliably higher than coherence with non-onset cortex in ds007445

  We adapted the EDF range-read loader and used the ds007445 file list, events and channel_groups metadata from this publication.

• usesThalamic SEEG pairs were not recruited earlier than white-matter pairs in 14 focal-seizure patients

  Uses the same dataset, channel groups and line-length approach. Adds the latency measure that this study said it did not measure.

• usesIn 53 ds007445 seizures, thalamic line-length rise followed SOZ but not white matter at z > 3

  Reuses its range-read EDF code, its 54-file seizure selection and its channel-group metadata copies. Extends its 0-20 s magnitude result to the onset latency of each region.

• usesIpsilateral thalamic recruitment was not significantly later than the seizure-onset zone or different from matched white matter in focal seizures

  We use its EDF range reader, its session choice and its labels. We measure the recruitment time, which that study did not measure.

• usesIn 16 patients, thalamic line length was above baseline at seizure start and end, with no clear further increase or post-offset change

  We use its byte-range EDF reader, its pre-processing, and its ds007445 metadata. We extend its onset analysis to the seizure end and the post-ictal period.

• usesIn 17 pediatric patients, thalamic line-length recruitment did not differ from non-SOZ cortex or white matter, but followed SOZ onset by about 13 s

  We used its ds007445 file list, its copies of events and channel-group metadata, its 53-seizure selection and its EDF Range-reading method. We measured the recruitment latency that it stated it did not measure. Our THAL set excludes NodHet and Tuber.

• usesIn 13 patients with SEEG, early ictal line-length recruitment did not differ between anterior and centromedian thalamic pairs in ds007445

  We used the archived per-pair line-length index table (results/pairs_R.csv) and the copy of the ds007445 participants_seizures.tsv. The R_ll, R_ll80 and R_hfa values and the ipsilateral nucleus labels from this package are the only signal inputs of the AN vs CM comparison.

• challengesIn 19 SEEG patients (OpenNeuro ds007445), early thalamic seizure recruitment (first 20 s, line length) is less than in clinically marked propagation cortex and not more than in contralateral cortex

  Its thalamic recruitment increase is not more than the increase in contralateral cortex, so it is not specific to the thalamus in the first 20 s.

• usesIn 19 SEEG patients (OpenNeuro ds007445), early thalamic seizure recruitment (first 20 s, line length) is less than in clinically marked propagation cortex and not more than in contralateral cortex

  We use its per-pair recruitment values, read provenance, and code.