Early ictal line length did not differ between anterior and centromedian thalamic nuclei in 13 SEEG patients

We compared early ictal line-length changes in ipsilateral anterior (AN) and centromedian (CM) thalamic stereoelectroencephalography pairs in OpenNeuro ds007445 v1.0.4. The analysis used an archived per-pair index and included 13 patients with both nuclei. The mean patient-level AN-minus-CM difference in the first 20 s after seizure onset was +0.091 log units (95% bootstrap CI -0.048 to +0.238); AN exceeded CM in 7 of 13 patients (exact sign-flip p = 0.243; Holm-adjusted p = 0.243). Neither nucleus exceeded ipsilateral white matter. A secondary comparison found a larger mean difference in limbic/temporal-focus patients (+0.288, n = 4) than in extratemporal-focus patients (+0.004, n = 9), but the difference was not significant (p = 0.095; Holm-adjusted p = 0.19). Other frequency bands showed the same pattern. These data do not show nucleus-specific recruitment in the first 20 s, but a true AN-CM difference of about 0.2 log units cannot be excluded. The sample was small; bipolar pairs may cross anatomical boundaries, labels were not checked by the authors, line length is sensitive to volume conduction, and AN and CM pairs shared shafts in some patients.

epilepsy · seizures · thalamus · anterior nucleus · centromedian nucleus · stereoelectroencephalography · line length · ictal recruitment

Admitted 2026-11-09 16:50 UTC1 citing publication

References

usesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c
We used the archived per-pair line-length index table (results/pairs_R.csv) and the copy of the ds007445 participants_seizures.tsv. The R_ll, R_ll80 and R_hfa values and the ipsilateral nucleus labels from this package are the only signal inputs of the AN vs CM comparison.
supportsEarly thalamic recruitment tracks FBTCS seizures, not diffuse spread, in ds007445 SEEG sci:sha256:04d584b2bc38f6b428b96bfbe8219213d5ee518f495b71897fe0e4974279621b
That work found that early thalamic recruitment in ds007445 is not thalamus-specific relative to other regions. We split the thalamus into AN and CM and also found no nucleus-specific recruitment and no excess over white matter, which agrees with a broad, non-specific early increase.
usesdoi:10.18112/openneuro.ds007445.v1.0.4
The analysis uses copied per-pair line-length indices and seizure focus labels from OpenNeuro ds007445 v1.0.4.

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supersedesIn 13 patients with SEEG, early ictal line-length recruitment did not differ between anterior and centromedian thalamic pairs in ds007445
Same analysis, code, inputs and results. The earlier README and body stated a 1-55 Hz band for R_ll; the correct band from 28e1dc1f is 1 Hz to min(150 Hz, 0.45 fs), i.e. 1-90 Hz at 200 Hz and 1-150 Hz at 2000 Hz.