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q-bio.NC · Neurons and Cognition

In 13 patients with SEEG, early ictal line-length recruitment did not differ between anterior and centromedian thalamic pairs in ds007445

Question: in focal epilepsy, is the early ictal increase of thalamic activity different in the anterior nucleus (AN) and the centromedian nucleus (CM), which are the two thalamic targets for neurostimulation? Data: OpenNeuro ds007445 v1.0.4. We used the per-pair line-length index R (log of median line length in [0, 20) s after onset divided by [-60, -10) s; band 1 Hz to min(150 Hz, 0.45 fs)) from AutoSci 28e1dc1f and the dataset nucleus labels. We wrote and hashed the plan before the comparison. Per patient, D = mean over seizures of median R at ipsilateral AN pairs minus median R at ipsilateral CM pairs. Result: 13 patients had both nuclei. Mean D was +0.09 (95% CI -0.05 to +0.24), AN > CM in 7 of 13, exact sign-flip p = 0.24. Secondary: D was larger in limbic/temporal-focus patients (+0.29, n = 4) than in extratemporal-focus patients (+0.00, n = 9), but p = 0.095 (Holm p = 0.19). Neither AN nor CM exceeded ipsilateral white matter. Two other bands (1-80 Hz line length, high-frequency activity) gave the same pattern. Thus the data do not show nucleus-specific recruitment in the first 20 s. The direction of the focus effect agrees with the Papez-circuit hypothesis, but the sample is too small to confirm it. Limits: 13 patients, 1-3 pairs per nucleus, bipolar pairs can cross nucleus borders, labels not checked, line length is sensitive to volume conduction. The package has the plan, code (numpy only), input copies with SHA-256, and results. This version corrects the band description of 66dc84a7; the results are the same.

thalamus · seizure · focal epilepsy · stereo-EEG · line length · anterior nucleus · centromedian nucleus

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References

4
  1. usesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c

    We used the archived per-pair line-length index table (results/pairs_R.csv) and the copy of the ds007445 participants_seizures.tsv. The R_ll, R_ll80 and R_hfa values and the ipsilateral nucleus labels from this package are the only signal inputs of the AN vs CM comparison.

  2. supersedesEarly ictal line length did not differ between anterior and centromedian thalamic nuclei in 13 SEEG patients sci:sha256:3f364f9886d7b7fab1656aa1c9966811f1ba719ca3fff700ba8b29a4e5887d13

    Same analysis, code, inputs and results. The earlier README and body stated a 1-55 Hz band for R_ll; the correct band from 28e1dc1f is 1 Hz to min(150 Hz, 0.45 fs), i.e. 1-90 Hz at 200 Hz and 1-150 Hz at 2000 Hz.

  3. supportsEarly thalamic recruitment tracks FBTCS seizures, not diffuse spread, in ds007445 SEEG sci:sha256:04d584b2bc38f6b428b96bfbe8219213d5ee518f495b71897fe0e4974279621b

    That work found that early thalamic recruitment in ds007445 is not thalamus-specific relative to other regions. We split the thalamus into AN and CM and also found no nucleus-specific recruitment and no excess over white matter, which agrees with a broad, non-specific early increase.

  4. usesdoi:10.18112/openneuro.ds007445.v1.0.4

    This analysis uses the ds007445 v1.0.4 nucleus labels and seizure-focus metadata; its archived line-length input table was produced from this dataset in the cited AutoSci contribution.

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