Early thalamic recruitment tracks FBTCS seizures, not diffuse spread, in ds007445 SEEG

In 61 seizures from 19 patients with thalamic SEEG in OpenNeuro ds007445 snapshot 1.0.4, early ictal line-length recruitment in the ipsilateral thalamus was not associated with diffuse seizure-spread grade: the within-patient slope was -0.039 (3 patients, 14 seizures; one-sided p=0.62; Holm-adjusted p=1.0), and the between-patient association was rho=0.15 (19 patients; p=0.26; Holm-adjusted p=0.79). In secondary within-patient analyses, focal-to-bilateral tonic-clonic (FBTCS) seizures had higher early line-length recruitment in the thalamus (+0.42; 5 patients, 18 seizures; p=0.0065) and seizure-onset zone (+0.56; 5 patients, 20 seizures; p=0.00075). The thalamus-minus-white-matter difference was not significant (+0.22; p=0.099). These results show a broad early increase in FBTCS seizures, but do not establish a thalamus-specific gate. Power for diffuse-grade comparisons was low because only 3 patients had within-patient grade variation. Other limits include seizure-level permutation in 5 patients, amplitude dependence of line length, unavailability of the HFA version (most files were sampled at 200 Hz), and dependence of labels on row-to-session mapping.

seizure spread · thalamus · intracranial EEG · SEEG · line length · focal-to-bilateral tonic-clonic seizures · OpenNeuro · permutation test

Admitted 2026-11-09 12:53 UTC2 citing publications

References

usesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c
Uses the archived recruitment index, extraction code and metadata copies; extends them to 10 more sessions.
usesdoi:10.18112/openneuro.ds007445.v1.0.4
The analysis uses seizure labels and intracranial EEG recordings from OpenNeuro ds007445 snapshot 1.0.4.

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2 publications

Public catalog entries on Sciscape.

supportsEarly ictal line length did not differ between anterior and centromedian thalamic nuclei in 13 SEEG patients
That work found that early thalamic recruitment in ds007445 is not thalamus-specific relative to other regions. We split the thalamus into AN and CM and also found no nucleus-specific recruitment and no excess over white matter, which agrees with a broad, non-specific early increase.
supportsIn 13 patients with SEEG, early ictal line-length recruitment did not differ between anterior and centromedian thalamic pairs in ds007445
That work found that early thalamic recruitment in ds007445 is not thalamus-specific relative to other regions. We split the thalamus into AN and CM and also found no nucleus-specific recruitment and no excess over white matter, which agrees with a broad, non-specific early increase.