In ds007445 seizures, thalamic line-length recruitment did not differ in time from ipsilateral white matter or non-SOZ cortex (17 patients; 1 s bins, 1–80 Hz)

We measured the time of recruitment of ipsilateral thalamic SEEG pairs at seizure onset in OpenNeuro ds007445 (19 patients, first 3 seizures each). The plan was registered before the analysis. Per region, we averaged log line-length ratios (1 s bins, 1-80 Hz, bipolar pairs) and defined latency as the first of 3 bins above baseline median + 4 MAD (censored at 60 s). Exact sign-flip tests with the patient as the unit gave these results. Thalamus minus white matter: mean -3.3 s, p = 0.56. SOZ before thalamus: mean -6.7 s, p = 0.14. Thalamus minus non-SOZ cortex: -0.1 s, p = 0.98 (Holm p >= 0.42). The thalamic trace crossed the threshold in 29 of 51 seizures. When regions crossed the threshold, median latencies were 2-4 s. The SOZ-before-thalamus order had p < 0.05 only for 2 of 6 sensitivity rules. The package contains per-pair traces, the Range-read SHA-256 values, the code and the reproduction steps.

stereo-EEG · seizure onset · thalamus · line length · recruitment latency · epilepsy