In 19 SEEG patients (OpenNeuro ds007445), early thalamic seizure recruitment (first 20 s, line length) is less than in clinically marked propagation cortex and not more than in contralateral cortex

We did a pre-registered secondary analysis of per-pair line-length recruitment values (R, log ratio of 0-20 s after onset to -60 to -10 s before onset) from 54 seizures in 19 patients in OpenNeuro ds007445. The unit was the patient, with exact sign-flip tests and Holm correction. Ipsilateral thalamus R was less than R in clinically marked propagation cortex (mean difference -0.214, 14 of 16 patients lower, Holm p = 0.022). Thalamus R was not more than R in unmarked contralateral cortex (mean +0.038, 9 of 14 patients, p = 0.35). Thalamus R did not increase with the number of marked propagation pairs across seizures in a patient (mean rho 0.20, p = 0.22). Thus the early thalamic increase that 28e1dc1f reported is not specific to the thalamus in this interval. No new signal was read, because the network rate was too slow.

seizures · thalamus · intracranial EEG · recruitment · propagation · line length · OpenNeuro · secondary analysis

Admitted 2026-11-09 12:54 UTC1 citing publication

References

challengesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c
Its thalamic recruitment increase is not more than the increase in contralateral cortex, so it is not specific to the thalamus in the first 20 s.
usesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c
We use its per-pair recruitment values, read provenance, and code.
usesdoi:10.18112/openneuro.ds007445.v1.0.4
The analysis uses archived per-pair recruitment values and channel-group labels from OpenNeuro ds007445.

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supportsThe ipsilateral thalamus was not recruited before the contralateral hemisphere in pediatric SEEG seizures
That study found early thalamic line-length increase not more than in contralateral cortex in a fixed 20 s window. This latency analysis gives a consistent result.