In pediatric SEEG, thalamic recruitment followed the seizure onset zone and was not earlier than white matter or cortex
We measured when each bipolar SEEG pair shows a sustained line-length increase after seizure onset. We used OpenNeuro ds007445 v1.0.4 (19 pediatric patients, 54 seizures, 3550 labelled pairs). We wrote and hashed the analysis plan before we computed features. The detector used a 1-80 Hz band, a robust z of 3 or more, a line-length ratio of 1.5 or more, and a 3 s sustain time. Pairs without detection were censored at 60 s. The patient was the unit of analysis. The seizure onset zone was recruited 29.5 s earlier than the ipsilateral thalamus (mean; 16 of 17 patients; exact sign-flip p = 4.6e-5; Holm p = 1.4e-4). The thalamus was not recruited earlier than ipsilateral white matter (mean thalamus minus white matter +11.4 s; p = 0.074; Holm p = 0.15) or ipsilateral non-SOZ cortex (+5.8 s; p = 0.37). Anterior and centromedian nuclei did not differ (n = 13; p = 0.64). In the first 60 s, only 37% of thalamic pairs reached the threshold. For the SOZ, the value was 82%. For white matter, it was 55%. The false detection rate in a pre-ictal sham window was 2-5%. Other thresholds and the label set of the prior study gave the same conclusions. The result applies to a line-length detector only. It can miss low-amplitude rhythmic thalamic changes. The package contains the code, per-pair line-length arrays, byte-range SHA-256 values and the plan.
pediatric epilepsy · stereo-EEG · thalamus · seizure onset · recruitment latency · line length · intracranial EEG
References
2- usesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c
We use its EDF range-read code, its session selection and its copied metadata. We add onset latency, which that study did not measure. We exclude Tuber and NodHet labels from the thalamus group, and we report its label set as a sensitivity analysis.
- usesdoi:10.18112/openneuro.ds007445.v1.0.4
The analysis uses EDF recordings, seizure events, and channel-group metadata from OpenNeuro ds007445 version 1.0.4.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- challengesIn one ds007445 feature set, SOZ-to-thalamus lag depended most on the pair summary rule across 144 detector settings
Its 25-30 s SOZ-to-thalamus lag depends on a median that includes censored non-recruited pairs; with recruited pairs only the lag is 0-13 s.
- usesIn one ds007445 feature set, SOZ-to-thalamus lag depended most on the pair summary rule across 144 detector settings
Archived line-length features and detector code are the input of this multiverse.
- usesIn 16 pediatric SEEG patients, the earliest archived seizure had lower SOZ AUC than later seizures, while averaging three seizures added 0.027 AUC
Original per-pair line-length extraction from ds007445 v1.0.4.
- usesThe ipsilateral thalamus was not recruited before the contralateral hemisphere in pediatric SEEG seizures
Input is the archived per-pair seizure latency table (results/pair_latency.csv) and detector of this publication.
- usesEarly ictal line length marks clinical SOZ pairs and non-SOZ maps repeat across pediatric seizures
The input is the archived per-pair line-length data (derived/*.npz) of this study. No new download was made.
- usesEarly thalamic line-length increase did not show a clear association with seizure duration in pediatric thalamic SEEG
We use its archived per-pair line-length arrays, pair-group table and copies of the ds007445 events files as the input data.