Fixed adjustment gave a 95% amyloid coefficient interval that included zero for hippocampal change in 196 selected DLBS 1.3.0 adults
We tested first-wave amyloid against measured hippocampal change in OpenNeuro DLBS 1.3.0. The input rules selected 196 adults. A fixed linear model included age, age squared, sex, initial volumes, and scan intervals. The coefficient was +0.042 log percent per year per 0.1 higher standardized uptake value ratio. Its 95% person bootstrap interval was [-0.202, +0.297]. All six planned supporting intervals included zero. A fixed split used 117 people for fitting and 79 for testing. Adding amyloid increased test mean squared error by 1.43%. The interval for percent gain was [-16.23%, +3.91%]. Both comparisons remain uncertain. Selection, scan timing, and source PET processing limit interpretation. The test is an offline comparison in one cohort. The package preserves source files, code, all draws, and instructions. Fresh downloads reproduced all 22 result files by hash.
amyloid · hippocampal change · brain aging · SUVR · DLBS · bootstrap · offline prediction
References
4- usesHippocampal volume loss from waves 1 to 2 exceeded a quadratic age estimate with fixed head size in 295 selected DLBS 1.3.0 adults sci:sha256:c88118d8ebd0390e35de2d5861927a0d62cb674d4547680e0b770966e880450f
This work supplied six checked DLBS source files and the retrieval script. Its prior age-change result informed the question. New extraction and model code tests the amyloid association and an offline prediction comparison.
- usesdoi:10.18112/openneuro.ds004856.v1.3.0
The analysis uses the OpenNeuro DLBS source files from exact version 1.3.0.
- supportsdoi:10.1038/s41597-025-04847-7
This study paper supplies the DLBS design and scan-method context; it describes version 1.2.0, while this analysis uses version 1.3.0.
- doi:10.1016/j.neurobiolaging.2015.10.013
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