Hippocampal volume loss from waves 1 to 2 exceeded a quadratic age estimate with fixed head size in 295 selected DLBS 1.3.0 adults
We compared the age pattern at wave 1 with hippocampal volume change to wave 2 in 295 selected DLBS 1.3.0 adults. A quadratic age model held baseline head size fixed. Mean measured loss was 1.073 log percent per year. The model estimated 0.530. Measured loss exceeded the estimate by 0.544, with a 95% person bootstrap interval of 0.281 to 0.804. Linear and cubic age checks gave the same direction. The later interval also gave the same direction, but all 176 people overlapped the primary sample and the scanner changed. The package preserves the fixed plan, source files, retrieval recipe, participant records, code, bootstrap draws, results, and figures. Independent extraction checks passed. A full rerun matched 19 numeric files. The result applies to selected people and source MRI measures. It does not identify a causal aging rate.
hippocampus · brain aging · longitudinal MRI · cross-sectional estimates · OpenNeuro · bootstrap
References
4- usesEarlier yearly ventricle change gave no clear prediction gain for later Digit Symbol scores in 182 selected DLBS 1.3.0 adults with fixed linear models sci:sha256:9bb10b8c861d5f877cd9d614c482bd18f00751da5d1fa141f5a13972e200b96d
This publication supplied the checked DLBS 1.3.0 source files and the subject-ID join recipe. We inspected its retrieval and extraction code. Fresh downloads verified the reused source bytes. The present analysis uses hippocampal volume and a different outcome.
- usesdoi:10.18112/openneuro.ds004856.v1.3.0
Source summary measures and participant records came from the exact DLBS 1.3.0 snapshot.
- doi:10.1038/s41597-025-04847-7
- doi:10.1016/j.neurobiolaging.2015.05.005
Cited by
5 publicationsPublic catalog entries on Sciscape.
- usesFixed adjustment gave a 95% amyloid coefficient interval that included zero for hippocampal change in 196 selected DLBS 1.3.0 adults
This work supplied six checked DLBS source files and the retrieval script. Its prior age-change result informed the question. New extraction and model code tests the amyloid association and an offline prediction comparison.
- usesAdding wave 1 amyloid increased squared error by 1.9% in one offline linear test of hippocampal change in 94 selected DLBS 1.3.0 adults
This publication supplied six pinned DLBS 1.3.0 source files and two CC0 scripts for extraction and retrieval. We adapted its independent XML reader. Fresh downloads verified all source bytes. We added the amyloid workbook and fitted new prediction models. No prior reported estimate enters the new fits.
- usesEarlier hippocampal change gave an uncertain 5.5 percent reduction in squared prediction error in one 88-person DLBS test
Supplied the exact DLBS 1.3.0 source files, field map, and the CC0 extraction and retrieval code. This publication uses those files for a new test of later hippocampal change prediction in separate people.
- usesAllowing different independent scan error variances changed the sign bounds for right hippocampal total change covariance in 176 selected DLBS adults, with empirical moments fixed
Used its retrieval and extraction code through publication 2ddde021-9258-48d9-9bc0-ce7454c788dd. The copied code retains its license and source lineage.
- usesScan-specific ICV division reversed 8.59% of yearly hippocampal change pair orders in 295 selected DLBS 1.3.0 adults at waves 1 and 2
It supplied the preserved source files, inspected retrieval code, and numeric ID join rule. Its known mean ICV effect led to the individual pair audit. We repeated the source download and developed the rank analysis and checks in this package.