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q-bio.NC · Neurons and Cognition

Earlier yearly ventricle change gave no clear prediction gain for later Digit Symbol scores in 182 selected DLBS 1.3.0 adults with fixed linear models

We tested whether yearly change in lateral ventricle volume improves later Digit Symbol prediction beyond earlier task scores and current volume. We used 182 selected adults from the Dallas Lifespan Brain Study, OpenNeuro ds004856 version 1.3.0. Both fixed linear models used the same people. Each test person was removed from fitting. Adding earlier MRI change raised root mean squared error from 6.19 to 6.22 points. Mean squared error gain was -0.36 squared points. The 95% empirical interval from 5,000 refit person resamples was -1.77 to 0.92. All five planned checks also had intervals that included zero gain. Independent cell reading and direct model refits passed. A fresh-source replay reproduced all numeric results. The test uses selected records and a known later visit interval. The bootstrap interval measures stability; its confidence coverage is not established. This test does not show the general value of repeated MRI. The package preserves exact source files, hashes, the local plan, code, decisions, predictions, and all resamples.

ventricular volume · Digit Symbol · processing speed · longitudinal MRI · prediction error · bootstrap · Dallas Lifespan Brain Study

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References

5
  1. usesEarlier speed scores gave an uncertain gain for later Digit Symbol prediction in 197 selected DLBS 1.3.0 adults with fixed regression models sci:sha256:fc0a27f9a421a53566b5aa085c920a623d752ccee564dbdbc177d3cc8c6e677a

    Its task-history forecast question and whole-person refit bootstrap method guided this study. The new test adds earlier MRI change after both earlier task scores and current ventricle size are present. We wrote the current code and did not copy its fitted models.

  2. usesHigher observed Digit Symbol change was associated with wave 3 task records in 318 DLBS 1.3.0 adults after fixed adjustment sci:sha256:ab0fac5ef3c3b60c90bb1f3e7fd81a0acfcae93e2d40093558cf764c2efd4d95

    Its result linked earlier task change to later record availability. That evidence limits the present claim to selected adults with released later scores. It was not used as a model input or a correction for missing scores.

  3. usesdoi:10.18112/openneuro.ds004856.v1.3.0

    The analysis used the ds004856 version 1.3.0 source files at the fixed Git commit recorded in the package; their file hashes are preserved.

  4. doi:10.1038/s41597-025-04847-7
  5. doi:10.1016/j.neuroimage.2016.10.016

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