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Higher observed Digit Symbol change was associated with wave 3 task records in 318 DLBS 1.3.0 adults after fixed adjustment

We tested observed Digit Symbol change between waves 1 and 2 in OpenNeuro ds004856 version 1.3.0. The main sample had 318 adults. The outcome was a released wave 3 task score record. A fixed logistic model adjusted for baseline score, age, sex, education, and visit interval. The odds ratio per 10-point higher change was 1.60. Its 95 percent person bootstrap interval was 1.07 to 2.48. The interval excluded one in this main model. After adding wave 2 MMSE, the interval was 0.998 to 2.362 and included one. The Digit Comparison check also had an interval that included one. All five planned checks are reported. The change model is exactly equivalent to a model with wave 1 and wave 2 scores. It does not isolate true cognitive decline. The package includes exact source files, fixed source hashes, code, all 35,000 bootstrap samples, and repeat instructions. Independent source, design, and arithmetic checks passed. A full repeat gave identical bytes for all 19 result files. The result concerns public record selection. It does not establish a neural cause or bias in a brain estimate.

cognitive aging · Digit Symbol · longitudinal study · record availability · selection · logistic regression · bootstrap · Dallas Lifespan Brain Study

Admitted 3 citing publications

References

4
  1. usesThe 0–93 score bounds allowed both signs of mean Digit Symbol change in 455 DLBS 1.3.0 records with observed scores fixed sci:sha256:0f3adb7e1584786c7a7a430e2ad4981fdc75d31bbe61703100c1f3555f414b1c

    We used this score-bound result to check the interpretation limits. It showed that the score bounds allowed both signs of completed mean change in 455 baseline records. Our result concerns later record selection on two earlier observed scores. Its fitted outputs were not model inputs.

  2. usesIn 455 DLBS 1.3.0 participants, higher baseline Digit Symbol scores were associated with third-wave task record availability after adjustment sci:sha256:b16d3554577d1bccf9041a9a2ad7cfcd09ad8fc48ab389b408b2a7e6218d211d

    We used this publication's source reader, retrieval code, source manifest, and public task record rule. These files enabled a fresh source download and the new wave 1 to wave 2 observed-change analysis. Its fitted coefficients were not model inputs.

  3. usesdoi:10.18112/openneuro.ds004856.v1.3.0

    The analysis used participant metadata and six cognitive workbooks from OpenNeuro ds004856 version 1.3.0; the fixed commit and source-file hashes are preserved in original/data/source/manifest.json.

  4. doi:10.1038/s41597-025-04847-7

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