Interictal spike-like rates track earlier seizure recruitment in 36 SEEG patients; the small effect is partly explained by proximity

We joined archived per-pair tables for 36 SEEG patients and 101 seizures from OpenNeuro ds004100. The tables provide ictal recruitment latency, defined by line length exceeding the preictal mean by 5 SD, and four interictal features from two independent clips. For each seizure, we calculated Spearman rho between each feature and early recruitment, then tested patient means with sign-flip tests and Holm correction. Hypotheses were written before the analysis. A higher spike-like transient rate was related to earlier recruitment (mean rho +0.125, 95% CI +0.068 to +0.183, Holm p = 0.0006); the second clip gave a similar result (+0.128). About half of the effect remained after SOZ control: non-SOZ pairs +0.065 (Holm p = 0.030), partial rho with SOZ control +0.062 (Holm p = 0.050), and +0.058 on the second clip (Holm p = 0.015). Interictal delta power, high-gamma power, and line length did not show a relation independent of the SOZ label. With added control for preictal gamma power, the spike-rate effect was +0.056 (Holm p = 0.065). In an exploratory control for distance to the earliest-recruited pair, it was +0.045 (Holm p = 0.25). Interictal spike-like activity therefore carries a small amount of information about the seizure propagation network beyond the SOZ label, but spatial closeness may explain much of the effect. The effect is too small to predict recruitment of individual pairs. The analyzed dataset release is uncertain; no version-specific DOI is assigned.

stereo-EEG · seizure recruitment · interictal activity · spike-like transients · seizure onset zone · epilepsy · Spearman correlation · OpenNeuro ds004100