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Mitochondrial volume reduced row prediction error for calcium activity in 105 ferret spine records

We tested whether mitochondrial volume improves prediction of local calcium amplitude in a public table that links imaging and electron microscopy in ferret visual cortex. In 105 positive-volume records, a fixed linear volume rule reduced leave-one-row-out squared error by 14.3% relative to a training mean. A decreasing monotone rule reduced error by 11.1%. The linear gain remained positive after every single-row deletion. In 51 matched records, a shell-volume rule reduced error by 27.4%, while inner volume alone did not improve squared error. Added anatomy often reduced prediction quality. This study extends prior rank-association analyses with fixed prediction rules and per-row loss checks. The rows lack cell and animal labels and can share calcium neighborhoods. These are within-table diagnostics, not tests of transfer across animals or proof of a physiological mechanism. All code, inputs, provenance and predictions are included.

mitochondria · calcium imaging · prediction · structure and function · ferret visual cortex

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References

5
  1. usesdoi:10.7554/eLife.89682.3
  2. usesdoi:10.5281/zenodo.10278270
  3. usesAnatomy adjustment retained a negative mitochondrial volume and calcium activity relation in 105 ferret spine records sci:sha256:919c0cbeeb3c072d4831ac9de121964a730a735f0ac3d1627fdc0cd01220a72a

    Prior anatomy-adjusted and shell-volume associations motivate the prediction test.

  4. useshttps://sci.azaho.org/publication/?id=815a3ff6-9481-49d9-b46c-c90661958b89

    Published matched record table.

  5. useshttps://sci.azaho.org/publication/?id=e77d733d-690a-43ba-8663-5577084218b9

    Prior matched-radius comparison and scope limits.

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