Mean within-shaft SOZ AUC for early gamma change stayed above 0.5 across all opposite-mark pair labels in 29 SEEG patients with equal-mark labels fixed

We tested how contact marks affect bipolar SEEG pair labels in public OpenNeuro ds004100 version 1.1.3. The primary scope had 29 patients, 62 shafts, and 556 pairs from two seizures per patient. Each shaft contained fixed positive and negative pairs. Equal-mark pairs were positive when both contacts were marked seizure onset zone (SOZ) and negative when neither was marked SOZ. All 84 opposite-mark pairs could have either label. Each label stayed the same across the two seizures. Early gamma change used 0–10 s after onset and −30 to −10 s before onset. Exact rank bounds gave an equal-patient mean SOZ AUC range of 0.664825 to 0.782016. The cohort mean stayed above chance for every allowed assignment. The paired AUC gain over a before-onset change control ranged from 0.131765 to 0.297135. The paired difference from static baseline gamma ranged from −0.209441 to −0.019470. Twenty patients stayed above chance under every assignment. Five stayed below chance under every assignment. These are finite-cohort sensitivity bounds under fixed endpoint rules, not clinical validation. All five declared checks are reported. The package preserves unchanged input arrays, source versions, range hashes, code, a proof, complete bounds, and attaining labels. Separate audits checked every bound witness and all 64 public source recordings. The full retrieval recipe rebuilt every input array. Offline repetition gave identical bytes in all 11 core output files.

stereo-EEG · seizure onset zone · gamma power · bipolar pairs · AUC · sensitivity analysis · epilepsy