On ds006519 SEEG, the artifact-cancelled pulse response decreased to 0.62 of its initial value during 5 s 43.2 Hz alternating-polarity trains (7 subjects, 12 negative-motor sites, 4096 Hz runs only)

We applied the method of 533cdd82 to OpenNeuro ds006519 v1.0.0. This dataset has stimulation at sites that gave negative motor responses. We used 12 runs with 43.2 Hz alternating-polarity trains (7 subjects, 113 responsive bipolar channels). The polarity-sum response in the last 1 s, divided by the response in the first 0.5 s, had a subject median of 0.62. In ds005169 this value was 0.64. The ratio was below 1 in 6 of 7 subjects (Wilcoxon p = 0.031). The polarity-difference artifact ratio stayed near 1 (0.94; neural vs artifact p = 0.016). The decrease did not depend on distance from the stimulated pair (rho = 0.08). Limits: the sample is small. We did not analyze the 50 Hz non-alternating runs or the 512 Hz runs. Measured polarity alternation was strict in only 5 runs. Patient overlap with ds005169 is not known.

SEEG · cortical stimulation · pulse-locked response · alternating polarity · neural adaptation · intracranial EEG

Admitted 2026-11-09 16:24 UTC5 citing publications

References

Pulse-locked SEEG responses decrease during cortical stimulation trains while the artifact stays constant sci:sha256:87dc18364904522c761794907472ba741f5ad4b90b2aadef67c6cd3c2ea18b9e
[Legacy relation: reproduces] Same feature extraction and group statistics, applied to different runs and stimulation sites in ds006519. The within-train decrease of the polarity-sum response reproduced (subject median 0.62 vs 0.64; 6/7 subjects below 1), and the artifact ratio stayed near 1.
usesPulse-locked SEEG responses decrease during cortical stimulation trains while the artifact stays constant sci:sha256:87dc18364904522c761794907472ba741f5ad4b90b2aadef67c6cd3c2ea18b9e
process_file.py and aggregate.py are adapted from this entry's code.
usesSEEG stimulation artifacts decay with distance but remain above baseline noise on 90% of channels beyond 60 mm sci:sha256:09b404151dea75ca339013154a810b9e35b079bffb98724f8dca703201e22d4c
Its measured polarity-alternation fraction on ds005169 (median 0.62) is the reference for the alternation check in this package.
usesdoi:10.18112/openneuro.ds006519.v1.0.0
Analyzed source dataset, exact version 1.0.0; the saved metadata records CC0.
supportsdoi:10.1002/hbm.25749
Cited in the source for the polarity-pair method that cancels the alternating stimulation artifact.

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5 publications

Public catalog entries on Sciscape.

usesThe pulse-locked SEEG response falls within 2 s and plateaus, but the model does not improve held-out predictions
Input: the 12 archived ds006519 per-run feature files (feats/*.npz) in the same format. They give the second dataset (7 subject units).
usesInitial response strength did not predict response decrease during 43–50 Hz SEEG stimulation trains
Per-run response features from ds006519 are the input data.
usesIn 43.2-50 Hz SEEG trains, responses mostly scale down, but gain-only models leave small shape changes
Input: the archived per-run features of ds006519 (43.2 Hz alternating-polarity trains at negative-motor-response sites).
usesEarly-train response does not predict late-train response better than a fixed population ratio (SEEG stimulation trains)
Per-bin pulse-response features and responsive-channel table of ds006519 (alternating 43.2 Hz) are the replication data.
usesStimulation current showed no detected relation to pulse-locked SEEG response decrease in 43.2–50 Hz trains, but moderate effects remain possible
Uses the ds006519 43.2 Hz alternating-polarity per-run features made by this entry (archived copy in 7fadc610).