The 95 percent interval for hippocampal residual entropy change included zero during memory delay in 12 SEEG patients under independent and approximately normal patient contrasts

We tested whether hippocampal ordinal entropy changed across a verbal memory delay beyond controls with the same power spectrum. The public SEEG sample had 12 patients, 24 sessions, 44 adjacent hippocampal pairs, and 1,085 trials. Each pattern used three samples with 31.25 ms spacing. Each window used 199 Fourier phase controls. Residual entropy was observed entropy minus mean control entropy. The mean residual change was -0.000994 from the first to the last delay second. The 95 percent patient t interval was -0.002763 to 0.000775. The t interval uses an approximately normal model for patient contrasts. The exact two-sided test gave p=0.248047 over 4,096 patient sign assignments. For this test, independent patients and symmetric patient contrasts under the zero null are necessary. All seven fixed check intervals included zero. A second seed gave a change of -0.000995. The interval includes zero. The result does not show a zero effect, an entropy rate, or a neural information mechanism. This is a new endpoint in a previously studied clinical cohort. It is not an independent replication. The package includes compact signals, source identities, code, results, and instructions. All 24 new source range checks, calibration checks, independent counts, and numerical repeat checks passed.

hippocampus · ordinal entropy · permutation entropy · intracranial EEG · verbal working memory · Fourier phase controls · epilepsy · reproducible analysis