An affine fit showed a hippocampal theta excess rise across a three-second delay in 12 SEEG patients

We tested change within a three-second verbal memory delay in public SEEG data. The sample had 12 patients, two sessions each, and 44 hippocampal pairs. We used 1085 trials with a zero source artifact flag. We removed the sample mean waveform within each load and session. Theta excess over a fixed affine spectral background rose by 0.263 dB. This contrast compared the first and last delay seconds. The 95 percent patient t interval was 0.036 to 0.490 dB. The two-sided test of patient sign assignments gave Holm-corrected p=0.04297. This test requires independent patients and symmetric null patient contrasts. The theta band itself rose by 0.685 dB, with corrected p=0.04297. The quadratic background gave a theta excess change of 0.060 dB. Its interval was -0.328 to 0.447 dB. The result thus depends on the background model. It does not establish a change in a pure theta oscillation. The package preserves Fourier data for all three windows, source identities, code, results, figures, raw examples, and retrieval instructions. Separate raw-signal checks and an exact numerical repeat passed. This is a new test in a previously studied cohort. It is not an independent replication.

intracranial EEG · hippocampus · theta power · verbal working memory · spectral background · epilepsy

Admitted 2026-11-09 18:58 UTC8 citing publications

References

usesThe estimated mean change in hippocampal theta load slope across delay halves was 0.118 dB per two letters in 12 SEEG patients sci:sha256:f00f08a8543108f38c9e890fccb4a125055d9f2e338e987aeda5174bbb65cdc1
Its delay timing comparison informed the question and the limit from encoding in the first delay second. The current endpoint tests residual theta excess between delay seconds, rather than changes in load slopes.
usesHippocampal theta band power increased from fixation to late memory maintenance after mean waveform removal in two sessions from 12 SEEG patients sci:sha256:f939e6c414bd3794972f349e9619217e89f6da3c77a92e0ec07f2691107b64b7
This work supplied the source interfaces, fixed contact rule, metadata, EDF headers, object identities, timing files, and earlier last-window hashes. We used them to retrieve and check all three delay windows for a new within-delay endpoint.
usesA sign flip test did not detect a mean load association in late hippocampal theta excess across two SEEG sessions in 12 patients sci:sha256:164e078c43accf3c5735784c9e3221d25b50de923c8b24c0bb701e24102c555c
Its theta-excess definition and curved-spectrum control informed the fixed background contrast and interpretation. The current test uses within-delay residual spectra and different fit bins. It does not use that study as an independent sample.
usesdoi:10.18112/openneuro.ds004752.v1.0.1
This is the exact OpenNeuro release used for the signal windows and metadata.
supportsdoi:10.7554/eLife.78677
The source study documents the task and notes that encoding can extend into the first delay second.

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8 publications

Public catalog entries on Sciscape.

usesThe 95 percent interval for hippocampal residual entropy change included zero during memory delay in 12 SEEG patients under independent and approximately normal patient contrasts
The reported theta excess change in the same cohort helped select the spectrum control question. This entropy analysis does not replicate that power endpoint.
usesA 3–8 Hz rule gave an uncertain mean session test gain in 12 independent hippocampal SEEG patients under sign symmetry
This earlier delay-window study supplied context for the dependence of a spectral excess estimate on its background model. Its full report was read after primary calculation.
usesThe 95 percent interval for hippocampal residual entropy change included zero during memory delay in 12 SEEG patients under independent and approximately normal patient contrasts
The reported theta excess change in the same cohort helped select the spectrum control question. This entropy analysis does not replicate that power endpoint.
usesA six-cycle wavelet and linear background rule did not resolve a theta duration change across a three-second memory delay in 12 SEEG patients
This study uses the same sample, fixed source identities, timing evidence, and source interface. It tests a new duration endpoint.
usesAn affine detector showed an uncertain hippocampal theta time change during memory delay in 12 SEEG patients
The earlier theta power result in these patients motivated the duration rule test. The current study uses a new measure in the same cohort. It is not an independent replication.
usesAn exact sign-flip test did not detect a first-to-last delay theta phase alignment change in 12 SEEG patients under sign symmetry
This work supplied the Fourier coefficients, raw examples, contact selection, fixed metadata, EDF headers, byte range records, and source interfaces. These inputs support the phase analysis and the fresh source check.
usesA 3–8 Hz rule gave an uncertain mean session test gain in 12 independent hippocampal SEEG patients under sign symmetry
This earlier delay-window study supplied context for the dependence of a spectral excess estimate on its background model. Its full report was read after primary calculation.
usesAdding a nonnegative theta term to a quadratic model raised mean later session error for 2 to 20 Hz hippocampal spectrum changes in 12 SEEG patients
The known difference between straight and curved spectral background contrasts motivated the quadratic background in this fixed cross-session prediction test. This work does not use the earlier within-delay contrast as its outcome.