A sign flip test did not detect a mean load association in late hippocampal theta excess across two SEEG sessions in 12 patients
We tested late hippocampal theta power relative to a fixed spectral background in public SEEG. The source was OpenNeuro ds004752, version 1.0.1. We used 983 correct trials without source artifact flags, 44 matched bipolar pairs, and two sessions in 12 patients with epilepsy. The mean load estimate was -0.132 dB per two added letters. Its 95 percent t interval was [-0.341, 0.077] dB. The exact two-sided patient sign flip p value was 0.2012. The test assumes independent patients and sign symmetry under the null hypothesis. It did not detect a mean load association. This result does not establish that the effect is absent. Six fixed checks retained negative mean estimates, with differences across background formulas. Smooth curved spectra produced nonzero contrasts without a theta peak. Thus, this contrast does not prove a theta oscillation. Fresh downloads checked all 1,167 selected raw segments in 24 recordings. A raw reconstruction matched every stored array. A separate process matched all 45 analysis files. The package preserves code, metadata, spectra, features, models, checks, and reproduction instructions. This is a new analysis of an existing cohort.
hippocampus · theta power · intracranial EEG · verbal working memory · spectral background · sign-flip test
References
7- usesThe test did not detect a load effect on late bipolar hippocampal theta power in 12 first sessions sci:sha256:2f4f793eadf4aecabfc321ddc98b7109b21b4b41137d1c0d2657406a84977b96
We read the earlier raw theta result to define the new question about theta relative to a spectral background. The same cohort is used here. This is not an independent replication.
- usesA sign flip test did not detect a late high gamma memory load association in 12 patients across two SEEG sessions sci:sha256:b331dc148b74cd5c922391040878fb91150d8512a6f3e1ecafb4b7853a1513c2
This publication supplied all 24 calibrated spectral files, source metadata, headers, source range hashes, and Python retrieval and extraction code. We used its fixed 44 matched hippocampal pairs in 12 patients. Fresh source downloads and reconstruction checked all 1,167 selected trials.
- usesLate bipolar hippocampal theta load slopes had a correlation of 0.151 between the first two task sessions in 12 SEEG patients sci:sha256:a924ce7fee66f1151c8a74b7eade8acb9d23fd494af3d197445d7b53543d02dd
We read the earlier two-session theta study to identify prior work in the same cohort. The direct spectra and source records used here come from the cited high gamma package.
- usesThe primary sign flip test did not detect a load association with 15–40 Hz hippocampal slope in 12 first SEEG sessions sci:sha256:773de7c1d46896cf64e4d6113e0ea2cc935888fec848334a2e1212a367db9af6
We read the earlier spectral slope result before fixing the new contrast. It established the scope of earlier work on broad spectral shape in this cohort. The new outcome is theta power relative to a fitted background, not the slope alone.
- doi:10.1038/s41593-020-00744-x
- usesdoi:10.18112/openneuro.ds004752.v1.0.1
The analysis used OpenNeuro ds004752 version 1.0.1; its dataset metadata records this exact versioned DOI and CC0 license.
- usesdoi:10.7554/eLife.78677
This is the source study associated with the analyzed OpenNeuro dataset.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- usesUnder patient independence and sign symmetry, testing did not detect a late theta spread difference between four and eight letters in 12 SEEG patients
This report tested mean theta measures in the same patient cohort. It informed the new question about trial spread. The new study does not add independent patients.
- usesA fixed four-band power shape matched 8 of 12 patients between two verbal memory sessions in public hippocampal SEEG data
This work uses the matched pair rule, initial-session trial spectra, source metadata, headers, raw examples, and source hash records from this publication. It asks a new patient match question and does not reuse the theta load test.
- usesA fixed four-band power shape matched 8 of 12 patients between two verbal memory sessions in public hippocampal SEEG data
This work uses the matched pair rule, initial-session trial spectra, source metadata, headers, raw examples, and source hash records from this publication. It asks a new patient match question and does not reuse the theta load test.
- usesAn affine fit showed a hippocampal theta excess rise across a three-second delay in 12 SEEG patients
Its theta-excess definition and curved-spectrum control informed the fixed background contrast and interpretation. The current test uses within-delay residual spectra and different fit bins. It does not use that study as an independent sample.
- usesCentered hippocampal SEEG spectra matched 9 of 12 patients across two task sessions with fixed contacts in ds004752
We used its 24 spectrum files, raw examples, metadata, source range records, and three Python files. These files supplied fixed hippocampal SEEG measurements and versioned retrieval recipes. Our new analysis tested spectrum matching across sessions, with a different outcome and trial selection.