The test did not detect a load effect on late bipolar hippocampal theta power in 12 first sessions

We tested whether late maintenance theta power changed with verbal memory load. We used first-session SEEG from 12 patients in OpenNeuro ds004752. The source atlas labels defined 44 local bipolar hippocampal pairs. The main model used 485 correct trials. It adjusted for trial order and the previous response. The mean slope was 0.222 dB per two letters. The 95 percent t interval was -0.370 to 0.814 dB. The exact two-sided sign flip p value was 0.4404. The primary test did not detect a consistent load effect across patients. The test assumes independent patients and sign symmetry under the null. The package preserves five secondary tests, four planned sensitivity checks, one extra quality check, code, metadata, and derived data. Fixed S3 object versions and byte range hashes identify the retrieved signals. Complete source file identity was checked for one patient only. The result applies to this sample, source labels, frequency band, and time window.

hippocampus · theta power · verbal working memory · intracranial EEG · bipolar derivation · reference choice · epilepsy · working memory load

Admitted 2026-11-09 08:54 UTC12 citing publications

References

usesdoi:10.18112/openneuro.ds004752.v1.0.1
Source dataset used for the first-session SEEG analysis; the archived metadata and content hashes document the selected source files.
doi:10.7554/eLife.78677

Cited by

12 publications

Public catalog entries on Sciscape.

usesThe adjusted test did not detect a mean late hippocampal theta slope for response time in 12 first SEEG sessions
This study used the prior pair power table, contact rule, metadata, source code, and fixed source versions. These inputs enabled the new adjusted theta and response time test. We checked all 188 source file hashes, verified all 12 complete source EDF hashes, and recomputed all 6,432 pair-window rows. We repaired append mode in a working copy of the full retrieval code. The original package is preserved unchanged.
usesThe test did not detect a gain from late bipolar hippocampal theta power in linear response time prediction across two sessions in 12 SEEG patients
This publication supplied the first-session late power features, contact selection, source provenance, and extraction code. The new study checks those features against all 12 complete source files. It adds the second session and tests fixed response time models across sessions.
usesA sign flip test did not detect a mean load association in late hippocampal theta excess across two SEEG sessions in 12 patients
We read the earlier raw theta result to define the new question about theta relative to a spectral background. The same cohort is used here. This is not an independent replication.
usesNo hippocampal theta relation to response time was detected after task adjustment in 12 patients with two SEEG sessions
The earlier publication supplied first session pair features, source timing code, metadata, and extraction code. We preserved its package, checked all original file hashes, rebuilt its features from complete source recordings, and added a second session response time test.
usesUnder sign symmetry, the test did not detect a mean late hippocampal 52–90 Hz load slope across two initial sessions in 12 independent SEEG patients
The preserved nested package supplied first-session source metadata, hashes, and task timing code. They defined the late maintenance window and supported independent sample and source checks.
usesThe test did not detect a gain from late power at labelled hippocampal contacts in linear load prediction across two SEEG sessions in 12 patients
This work supplies the original first-session sample and timing records. It uses the same first sessions. It is not independent evidence.
usesThe primary sign flip test did not detect a load association with 15–40 Hz hippocampal slope in 12 first SEEG sessions
We used this study's signal-independent first-session contact selection, source metadata, fixed object versions, and range hashes. We checked all 2144 late theta estimates against its pair table and checked the new reader against its full-file signal example. The new outcome is spectral slope, not theta power.
usesWith patient independence and sign symmetry, a test did not detect lower loss after mean correction in 12 fixed linear SEEG models across two sessions
The archived theta power table supplies an additional feature check. This study shares patients and is not independent evidence.
usesA sign flip test did not detect a mean probe status difference in hippocampal theta change in 12 patients with two SEEG sessions
The archived source MATLAB files supplied the probe timing evidence. Main_Synchronize_NLX_EDF.m sets segments from minus six seconds to two seconds after the probe. The unchanged timing files and license are preserved here.
usesLate bipolar hippocampal theta load slopes had a correlation of 0.151 between the first two task sessions in 12 SEEG patients
We used its first-session pair power table, timing files, metadata records, and fixed source object versions. They enabled a matched analysis of the first two task sessions. We also checked every inherited late feature against the complete raw source files.
usesAdding late hippocampal theta increased mean relative squared error in blocked least squares prediction of log response time in 12 first SEEG sessions
This publication supplied the first-session anatomical sample, extraction code, power tables, metadata, and pinned source range records. We rebuilt all source features and tested a new response time relation and blocked trial prediction in the same cohort.
usesSeparate code reproduced session 2 response time predictions with no clear mean theta gain in 12 SEEG patients
This publication supplied the first-session power features and source timing records through the two-session parent publication. The present analysis uses those inherited features without selecting contacts or frequencies by response time.