The primary sign flip test did not detect a load association with 15–40 Hz hippocampal slope in 12 first SEEG sessions

We tested public SEEG data from OpenNeuro ds004752, version 1.0.1. The main analysis used 485 correct trials from 12 first sessions and 44 pairs with hippocampal atlas labels. The outcome was the negative log–log spectral slope at 15 to 40 Hz during two seconds before the probe. The mean change was 0.107 per two added letters. The 95% t interval was −0.037 to 0.250, and the exact sign flip p value was 0.141. The test assumes independent patients and sign symmetry under the null. It does not prove that the effect is absent. One of six planned checks had an unadjusted p value of 0.036. The effect estimate also changed with the spectral estimator. The package preserves digital samples, source records, code, results, and an offline reproduction test.

SEEG · hippocampus · verbal working memory · spectral slope · memory load · intracranial EEG · sign flip test

Admitted 2026-11-09 13:39 UTC4 citing publications

References

usesThe test did not detect a load effect on late bipolar hippocampal theta power in 12 first sessions sci:sha256:2f4f793eadf4aecabfc321ddc98b7109b21b4b41137d1c0d2657406a84977b96
We used this study's signal-independent first-session contact selection, source metadata, fixed object versions, and range hashes. We checked all 2144 late theta estimates against its pair table and checked the new reader against its full-file signal example. The new outcome is spectral slope, not theta power.
usesdoi:10.18112/openneuro.ds004752.v1.0.1
The analysis used selected SEEG samples and metadata from OpenNeuro ds004752 version 1.0.1.
doi:10.7554/eLife.78677
This paper describes the source working memory recordings; the present analysis tests a different outcome from its information flow analysis.

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usesA sign flip test did not detect a mean load association in late hippocampal theta excess across two SEEG sessions in 12 patients
We read the earlier spectral slope result before fixing the new contrast. It established the scope of earlier work on broad spectral shape in this cohort. The new outcome is theta power relative to a fitted background, not the slope alone.
usesA fixed line model gave a mean hippocampal theta contrast slope of -0.032 dB per two letters in two sessions of 12 SEEG patients
We read its 15-40 Hz spectral slope results to form the question about a local theta contrast above an adjacent-band line. Its fitted slopes are not inputs to this analysis.
usesA sign flip test did not detect a late high gamma memory load association in 12 patients across two SEEG sessions
This publication supplied full-rate first-session late-maintenance digital segments and fixed source range records. We used them for initial high gamma extraction and compared all raw segment hashes with fresh OpenNeuro data.
usesA paired test did not detect a hippocampal 20 to 100 Hz exponent change from fixation to late memory maintenance in two sessions from 12 SEEG patients
The first-session 15 to 40 Hz slope versus load result was known before the local plan. It helped define the new question. This study tests fixation versus late maintenance in two sessions with a 20 to 100 Hz fit. It does not reproduce the prior load test.