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q-bio.NC · Neurons and Cognitioneess.SP · Signal Processing

A fixed line model gave a mean hippocampal theta contrast slope of -0.032 dB per two letters in two sessions of 12 SEEG patients

We tested memory load and hippocampal theta spectral shape in OpenNeuro ds004752 version 1.0.1. A fixed contrast compared 4 to less than 8 Hz log power with a line fitted to adjacent bands. The analysis used 983 correct trials, 44 matched bipolar pairs, and two sessions in each of 12 SEEG patients with epilepsy. Each patient had equal weight. The mean slope was -0.0322 dB per two letters. The 95% t interval was [-0.2968, +0.2324]; the exact patient sign-flip test gave p=0.876953125. The interval requires independent, approximately normal patient estimates. The sign-flip test requires independent patients and sign symmetry under the null. The result does not establish a zero slope or a change in an isolated theta oscillation. The contrast removes a straight log-frequency background change, but nearby peaks and curvature can change it. Fresh public source ranges reproduced all 1,167 trial spectra in the 24 selected recordings. A fresh Python installation also reproduced the numerical analysis. The archive includes code, compact spectra, trial tables, source pins, checks, and instructions for offline and source-data repeats.

hippocampus · theta · spectral shape · stereoelectroencephalography · verbal working memory · spectral contrast · patient-level inference

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References

6
  1. usesThe estimated mean change in hippocampal theta load slope across delay halves was 0.118 dB per two letters in 12 SEEG patients sci:sha256:f00f08a8543108f38c9e890fccb4a125055d9f2e338e987aeda5174bbb65cdc1

    We read its early and late theta power results to form the question about late-maintenance spectral shape. Its fitted slopes are not inputs to this analysis.

  2. usesThe primary sign flip test did not detect a load association with 15–40 Hz hippocampal slope in 12 first SEEG sessions sci:sha256:773de7c1d46896cf64e4d6113e0ea2cc935888fec848334a2e1212a367db9af6

    We read its 15-40 Hz spectral slope results to form the question about a local theta contrast above an adjacent-band line. Its fitted slopes are not inputs to this analysis.

  3. usesAdding late hippocampal theta power increased mean log loss by 0.0104 in fixed models tested across two sessions from 12 patients sci:sha256:5e2859c3852065d6cfd6d5d6292c8b555c7be3acddac9b13dcfa13411b26e91a

    We used its all-trial spectra, matched sample records, metadata, EDF headers, source hashes, and retrieval code. We checked 295 used archive files. We built a new fixed spectral contrast and retrieved all selected source trial windows. The patient sample is the same.

  4. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    This is the exact OpenNeuro snapshot used for the source recordings and metadata.

  5. usesdoi:10.7554/eLife.78677

    This paper describes the source verbal working memory recordings and task.

  6. doi:10.1038/s41593-020-00744-x

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