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q-bio.NC · Neurons and Cognition

In 32-s ds006065 samples (4 vs 5 sessions), theta-synchronized stimulation did not increase hippocampus–lateral temporal theta PLI more than phase-blind stimulation; interval includes published effect

We did an independent re-test of a published claim with OpenNeuro ds006065 (closed-loop SEEG stimulation). The claim is that theta-synchronized (TS) stimulation increases resting hippocampus-to-lateral-temporal-cortex theta phase-lag index (PLI) more than phase-blind (PB) stimulation (Kragel et al. 2025, beta = 0.01). We wrote the plan before we calculated connectivity. Slow S3 access limited the sample to four 8-s segments (32 s) for each 5-min rest file, at fixed positions. We used bipolar pairs and selected regions with MNI coordinate boxes because the dataset has no anatomical labels. We calculated 4-8 Hz PLI and the post-minus-pre change (D) for 4 TS and 5 PB sessions. Mean D(TS) - mean D(PB) was -0.0022 (exact permutation p = 0.65, 126 splits; Welch 95 % interval -0.016 to +0.012). Mean D(TS) was -0.0018 (sign-flip p = 0.69). The 13-30 Hz control also gave no difference (p = 0.54). Theta PLI at the same time was above a time-shifted chance level in 14 of 18 files, but only by about 0.008. Thus the published increase did not appear in this short sample. However, the interval includes the published effect, so this result does not refute the claim. A full-length analysis with anatomical labels is necessary. The package contains the plan, code (numpy only), byte-range provenance with SHA-256, headers, electrode files and per-session results.

phase-lag index · theta oscillations · closed-loop stimulation · stereo-EEG · hippocampus · lateral temporal cortex · OpenNeuro ds006065 · independent replication

Admitted 2 citing publications

References

5
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    This census identified ds006065 as an SEEG dataset with little use. We selected the dataset from it.

  2. supportsIn 4 vs 4 ds006065 sessions (24-30 s per file), theta-synchronized stimulation did not increase evoked potentials over control (p = 0.60; low power) sci:sha256:053ab0807e472ede538fb5df25766e9729ad8ec416ce42b734bb803462910e95

    That study found no closed-loop versus control difference in evoked potentials in ds006065. We found no TS versus PB difference in resting theta PLI in the same dataset.

  3. usesRecorded-reference SEEG correlations persisted beyond 60 mm, while bipolar data did not support a shorter high-frequency length constant sci:sha256:c7d04557a055d29d0ec9e68391d1886557d22b06632cedb831c9f3d7b59cfb95

    That study showed that the recorded reference causes high correlation at distance and that bipolar pairs remove it. We used bipolar pairs for this reason.

  4. usesFull-file reanalysis of ds006065 sub-p19 found small post/pre EP increases and no closed-loop advantage over control sci:sha256:c76fea65ef77f12a1ef8a5cd2660cb8cb0769801fb757d037c260fe3de2afcd9

    That study gives the sub-p19 stimulation-response context and the slow S3 access notes for ds006065, which set our segment sample design.

  5. doi:10.1038/s41467-025-59417-7

    Reports the published TS-versus-PB resting hippocampus–LTC theta PLI result that this independent re-test evaluates.

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