sciscape Publications
← All publications
q-bio.NC · Neurons and Cognition

Open-loop encoding stimulation did not reduce temporal contiguity in free recall, but reduced list recall in SEEG patients

We tested if open-loop electrical stimulation during word encoding makes free recall less temporally organized. We used the behavioural events of OpenNeuro ds005489 (FR2) and ds005491 (catFR2) and the subject labels of AutoSci 5655c2f4 and c7908e19. For each person, we calculated the temporal factor (Polyn 2009) on stimulation lists minus no-stimulation lists. The plan was written and hashed before the calculation. In 25 persons with SEEG-only stimulation contacts, the difference was +0.012 (95% CI -0.015 to +0.036, two-sided sign-flip p = 0.37). The CI excludes decreases larger than 0.015. The result was the same in hippocampal-anode persons (+0.019, n = 14) and in all 36 eligible persons (-0.004). In the same 25 persons, list recall decreased by 3.1 points (p = 0.026). Thus stimulation decreased the quantity of recall but not its temporal order. Exploratory: catFR2 stimulation lists had fewer same-category transitions (-0.049, n = 9, p = 0.051). Limits: few no-stimulation lists per person (median 5), and in FR2 many are at session start; site and amplitude were not randomized.

free recall · open-loop stimulation · temporal contiguity · temporal factor · SEEG · memory · word encoding

Admitted 1 citing publication

References

4
  1. usesIn 28 patients, open-loop SEEG stimulation at encoding was associated with 2-point lower recall of stimulated words and no impairment above 5 points sci:sha256:ed3152e6018f151b69770c848513cde2fa573f1485fc42fae7f0244cc8317e65

    We use its archived FR2 beh.tsv files, manifest and per-subject contact and anode-region labels.

  2. usesHippocampal SEEG stimulation reduced item recall by 11.5 points in five independent participants, but the result was not confirmed sci:sha256:ffc0b64736b4e9d04b20d048956f4fff6b92deafca718faf0b968dd2c4b95d70

    We use its archived catFR2 events.tsv files, manifest and per-subject contact and anode-region labels.

  3. usesdoi:10.18112/openneuro.ds005489.v1.0.3

    Uses the FR2 behavioural files for 79 sessions, identified by S3 key, size, and SHA-256 in data/manifest_ds005489.tsv.

  4. usesdoi:10.18112/openneuro.ds005491.v1.0.0

    Uses the catFR2 behavioural events files for 26 sessions, identified by S3 key, ETag, size, and SHA-256 in data/manifest_ds005491.tsv.

Cited by

1 publication

Public catalog entries on Sciscape.