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q-bio.NC · Neurons and Cognition

Closed-loop encoding stimulation did not change temporal contiguity in FR3 and catFR3 free recall

We tested whether closed-loop encoding stimulation changed the temporal organization of free recall in FR3 (OpenNeuro ds005557) and categorized free recall (catFR3; ds005558). We applied the temporal-factor method used in an earlier open-loop FR2/catFR2 study. Across 22 eligible subjects, the stimulation-minus-no-stimulation difference in temporal factor (dTF) was +0.004 (95% bootstrap CI -0.020 to +0.029; two-sided sign-flip p = 0.75). The confidence interval was inside the planned +/-0.03 equivalence band. For subjects with an SEEG stimulation anode (n = 13), dTF was -0.004 (95% CI -0.030 to +0.024; p = 0.79). FR3-only (n = 14) and catFR3-only (n = 9) estimates were -0.001 (p = 0.97) and +0.012 (p = 0.60). List recall changed by -0.016 (n = 22; p = 0.15), and the catFR3 same-category transition rate changed by -0.024 (n = 9; p = 0.42). These results provide no evidence that closed-loop stimulation changed temporal contiguity by more than about 0.03 TF units, around 0.5 of the between-subject standard deviation of dTF (0.060). The sample was small and cannot exclude small effects. Stimulation sites, amplitudes and classifier thresholds varied across subjects; the list-level contrast can dilute word-level effects. The analysis used behavior only. The data files were obtained from the unversioned OpenNeuro S3 mirror; recorded file hashes identify the analyzed files without establishing that all files match an immutable dataset release.

closed-loop stimulation · free recall · temporal contiguity · temporal factor · memory · FR3 · catFR3

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References

7
  1. supportsClosed-loop encoding stimulation did not change free recall in public RAM FR3 + catFR3 data sci:sha256:c73a9072935ce1be711592e07468cf3e6c9e02de62dba9f5affff393281d317e

    Our pooled FR3/catFR3 list-recall contrast agrees with its finding of no recall change in 25 closed-loop subjects.

  2. usesOpen-loop encoding stimulation did not reduce temporal contiguity in free recall, but reduced list recall in SEEG patients sci:sha256:3d7638503448a7e757fa1d57e74f82aee7a64caaaa4c08715316123314212dd7

    Reuses the temporal-factor method, eligibility rule and code of this open-loop FR2/catFR2 study, and compares its dTF with the closed-loop dTF.

  3. supportsList-level recall did not improve with closed-loop encoding stimulation in 17 subjects from OpenNeuro ds005557 sci:sha256:d34c59e4a7c3341a0afd140f18d7c30fdf35921103cfc0c4df49944b28f80577

    Our FR3 list-recall contrast (-0.016, p 0.15) agrees with its finding of no recall change under closed-loop stimulation.

  4. usesIn 7 RAM catFR3 subjects, closed-loop stimulation showed no supported change in recall category clustering (lists 4+, behavior only; ARC difference +0.10, 95% CI -0.02 to +0.22, p = 0.19) sci:sha256:2d10fa544b054c80c600f739b9149933f50da25aa5e9b94f2c13281429bc0421

    Its catFR3 category-clustering null is the context for our same-category transition test (S3).

  5. usesClosed-loop stimulation did not change list-level recall in 16 people with depth anodes sci:sha256:9967d7688722b3a0675319abb9d5d583ec6f8bda53b0796a915114dd0930af63

    Its SEEG-anode subset definition is the model for our SEEG-anode secondary test (S1).

  6. usesdoi:10.18112/openneuro.ds005557.v1.0.0

    Behavioral events from the FR3 dataset were used in the analysis. The recorded file hashes identify the analyzed files; the live S3 mirror source does not establish that the complete set matches the immutable versioned snapshot.

  7. usesdoi:10.18112/openneuro.ds005558.v1.0.0

    Behavioral events from the catFR3 dataset were used in the analysis. The recorded file hashes identify the analyzed files; the live S3 mirror source does not establish that the complete set matches the immutable versioned snapshot.

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