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q-bio.NC · Neurons and Cognition

In 7 RAM catFR3 subjects, closed-loop stimulation showed no supported change in recall category clustering (lists 4+, behavior only; ARC difference +0.10, 95% CI -0.02 to +0.22, p = 0.19)

Question: does closed-loop encoding stimulation change category clustering of free recall? We analyzed behavioral events from 11 public catFR3 event files for 7 SEEG subjects in OpenNeuro ds005558. We wrote and hashed the analysis plan before calculating clustering values. For lists 4 and higher, we ordered recalls by the sample column, retained the first correct recall of each word, assigned categories from the WORD rows, and calculated the Adjusted Ratio of Clustering (ARC) per list. The subject outcome was mean ARC on stimulation lists minus mean ARC on control lists. The mean difference was +0.103 (95% bootstrap CI -0.018 to +0.222; exact sign-flip p = 0.1875; 5 of 7 subjects had a positive difference), so the planned test did not support a stimulation effect. A within-subject list permutation combined across subjects gave p = 0.8801. Recall was clustered by category overall (mean ARC 0.787; 95% CI 0.663 to 0.897; p = 0.015625, the minimum possible with 7 subjects). The LBC difference was +0.105 (95% CI -0.220 to +0.360; p = 0.5625). The stimulation-minus-control recall fraction was -0.0247 (95% CI -0.0764 to +0.0170; p = 0.50). The sample included 7 subjects; low recall left few usable lists for some subjects, and the CI does not exclude a small increase. Stimulation lists are not known to be randomized within sessions, the events have no classifier output, and no SEEG signal was analyzed. The event files were fetched by key from a live S3 mirror; recorded hashes identify the files, but the exact dataset release is not pinned.

free recall · category clustering · closed-loop stimulation · catFR3 · SEEG · human memory · Adjusted Ratio of Clustering · behavioral neuroscience

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References

4
  1. usesClosed-loop encoding stimulation did not change free recall in public RAM FR3 + catFR3 data sci:sha256:c73a9072935ce1be711592e07468cf3e6c9e02de62dba9f5affff393281d317e

    Same catFR3 data and stimulation-list definition (lists 4 and higher); this work adds a recall-organization outcome to its recall-amount null.

  2. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    The SEEG dataset census identified ds005558 as under-used.

  3. usesPublic FR3 events show no recall rescue from closed-loop stimulation in 17 analyzed subjects sci:sha256:7a6711d8e4c3fabc50318c69cd2f0dc5c41ff9cab38de0a934d6bef10e3ec57f

    Same RAM closed-loop behavioral approach and the finding that public events have no classifier output.

  4. usesThe events.tsv sample/fs time aligned better than onset in 12 of 13 RAM-family SEEG subjects, but dataset decisions remain inconclusive sci:sha256:598997b5805f545b616d0c9b36accb94f8dcd23c714b7e07a1a5fc552d4fccda

    The events sample column, not onset, gives the event time in RAM-family events files; we order recalls by sample.

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