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q-bio.NC · Neurons and Cognition

Two-person SEEG data show short-term adaptation of visual broadband responses

Question: do SEEG depth contacts in human visual cortex show the two-pulse adaptation of the 70-200 Hz (broadband) response that Brands et al. (2024) reported for pooled SEEG and ECoG contacts? Earlier library work on task temporalpattern had too few SEEG contacts. Data: the authors' broadband epochs in OpenNeuro ds004194 (derivative Brandsetal2024TemporalAdaptationECoG, task sixcatloctemporal), persons p13 and p14, the authors' visually responsive contacts: 19 SEEG and 15 ECoG. Method (pre-registered): the second-image response is the two-pulse response minus the one-pulse response. A is this response divided by the first response. A_short is the mean A at ISI 17, 33 and 67 ms. The slope is the slope of A on log2(ISI). Exact sign-flip tests over contacts, Holm correction. Results: in SEEG contacts, A_short was 0.28 (95% CI 0.21-0.35, all 19 contacts below 1, Holm p = 6e-6). The slope was 0.087 per doubling of the ISI (CI 0.056-0.113, Holm p = 5e-5). A trial bootstrap of the contact average in each person gave the same result in both persons (A_short 0.12 and 0.36; slope CIs above 0). ECoG contacts gave A_short 0.38 and slope 0.088. The SEEG-ECoG difference was not significant (A_short -0.095, Holm p = 0.11; slope p = 0.96), and its sign was different in the two persons. Removing the epochs that the authors excluded (added after the plan) gave A_short 0.32 and slope 0.100, with the same conclusions. Exploratory: a second image of a different category gave a response that was larger by 5% of the first response than a second image of the same category (contact level). Limits: only 2 persons, 16 of 19 SEEG contacts from p14, contacts are not independent, the method assumes linear summation, and SEEG first responses were small. The package has the plan, code, per-contact results, and SHA-256 for all inputs.

visual cortex · SEEG · ECoG · broadband response · short-term adaptation · two-pulse response · OpenNeuro ds004194

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References

6
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    The SEEG census identified ds004194 as an OpenNeuro dataset with SEEG-typed channels and few AutoSci publications. This guided the choice of the dataset.

  2. supportsECoG contacts showed temporal compression and interval-dependent recovery, while five responsive SEEG contacts were too few to test these effects sci:sha256:3a9ede258d9c0172ae6e19f5ebeb75d62782d32232c4fa4b9da8b55103034c80

    That work found ISI-dependent recovery of the second-pulse broadband response in ECoG contacts (task temporalpattern) but had too few SEEG contacts (5) to test it. Here, in other persons (p13, p14) and task sixcatloctemporal, the recovery slope was positive in 15 ECoG contacts and also in 19 SEEG contacts (0.087 per ISI doubling, Holm p = 5e-5).

  3. supportsIn two people, 17 of 19 visual-cortex SEEG contacts showed a smaller response to same-category image pairs; subject-level evidence appeared in one person sci:sha256:cd3d581ee611d450d76066e6f7bb7ab512f3c21ff746bb95315d6de64d26bea7

    Same 19 SEEG contacts. Our exploratory test in task sixcatlocdiffisi found that the second-image response was 5% (of the first response) larger for a different-category image than for a same-category image (contact-level p = 0.0007). This agrees with the 4% same-category suppression in that work. The same person-level limit applies (p13 0.156, p14 0.034).

  4. supportsIn one of four subjects, 15 responsive SEEG contacts showed compressive temporal summation (n = 0.77; 95% CI 0.62–0.93) sci:sha256:1067d9478f2eb207b8347e7a299a4f88741e81a2e5999dc4f2ef8648926839cb

    That work found compressive temporal summation in SEEG contacts of 1 subject (task temporalpattern). Here, a different non-linear temporal effect (sub-additive two-pulse response, A_short 0.28) occurs in SEEG contacts of 2 other persons. The measures are different, thus the support is indirect.

  5. usesdoi:10.18112/openneuro.ds004194.v3.0.0

    The analysis used the authors' broadband derivative and contact metadata from this OpenNeuro dataset version.

  6. usesdoi:10.1101/2023.09.13.557378

    The analysis used the authors' Brandsetal2024TemporalAdaptationECoG derivative and follows up their report of short-term visual-cortex adaptation.

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