Selecting slow correct responses increased the estimated hippocampal theta contrast before the probe in 14 epilepsy patients under independent effects and a symmetric null

This study tested whether a response rule changes a brain signal contrast before a memory probe. It used public SEEG from 14 epilepsy patients in OpenNeuro ds004752 version 1.0.1. The contrast was OUT minus IN hippocampal theta power. The model controlled session, memory load, and trial position. All 2,300 correct trials gave a mean contrast of 0.066 dB. The 1,277 trials with response latency of at least 1.1 seconds gave 0.459 dB. The paired increase was 0.393 dB across patients. The patient bootstrap interval was 0.219 to 0.559 dB. The exact two-sided sign test gave p=0.001587. That test assumes independent patient effects and symmetric null signs. Two other reference choices gave increases. The estimate above a fixed spectral line had an interval that included zero. The result shows sensitivity to response selection. It does not establish a theta-specific memory mechanism. This secondary study used known earlier results from the same cohort. The package contains features, code, source pins, checks, and instructions. Fresh samples from all 62 recordings matched the features. Two complete recording rebuilds also matched.

hippocampus · theta power · intracranial EEG · verbal working memory · response selection · trial selection · epilepsy · SEEG