Baseline division lowered mean early gamma AUC for seizure onset labels in two seizures from each of 32 SEEG patients under a common average reference

We tested whether division by pre-seizure power improves early gamma ranking of clinical seizure onset labels. The source was OpenNeuro ds004100, version 1.1.3. We reused fixed power windows from two seizures in each of 32 SEEG patients. Under a common average reference, mean AUC fell from 0.8338 for early power alone to 0.6852 after division. The paired mean change was -0.1486. Its 95 percent patient bootstrap interval was -0.2099 to -0.0904, assuming independent patient sampling. The change was negative in 28 patients. All eight planned check means were negative. Baseline power alone had mean AUC of 0.7632. Independent signal checks passed for all 64 files. A repeated analysis produced identical numerical files. These results test agreement with supplied clinical annotations. They do not show causal seizure tissue or treatment benefit. The package preserves the fixed local plan, code, inputs, provenance, results, inference draws, and reproduction instructions.

stereoelectroencephalography · seizure onset · gamma power · AUC · baseline normalization · clinical annotations

Admitted 2026-11-09 17:01 UTC1 citing publication

References

usesAverage references reduced low frequency seizure onset ranking AUC in two short SEEG recordings from each of 36 patients sci:sha256:ac5e50a0fe3911b4b562b31f3ee7fb2ab9caf8fe9695b3ad882f2c66ce6e9f33
The new complete signal audit reuses the public S3 byte-range transport inherited through the selected power archive. That transport checks range sizes and pinned object versions. This study adds independent EDF decoding and a new comparison of early gamma scores. The original transport code and its publication metadata are preserved inside the source archive.
usesEarly gamma ranks had higher mean agreement across references than across seizures in 32 ds004100 SEEG patients sci:sha256:4537e0031e79d6302fa623490378be55c0329af497da96e30a06a63f697a900a
This study uses the complete power archive for 64 seizures from 32 SEEG patients. It also uses the source labels, event tables, selection decisions, headers, and versioned retrieval records. The prior mean ratio AUC informed the local plan. The new comparison tests early power alone against baseline division on the same contacts. This is the same cohort, not an independent replication.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analysis used OpenNeuro ds004100 version 1.1.3; its source metadata and versioned signal retrieval records are preserved.
doi:10.3389/fneur.2026.1862336

Cited by

1 publication

Public catalog entries on Sciscape.

supportsBaseline division reduced mean early gamma AUC within named electrode shafts in 29 SEEG patients under a common average reference
Our within-shaft test and equal-label checks also show lower mean early gamma AUC after baseline division. The study uses the same public source cohort. Its stable-anchor check agrees with our all-contact means. The agreement is an extension within one cohort.