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eess.SP · Signal Processing

Mixed gains gave 1.86% lower mean nominal 50 to 250 ms SEEG error with ten calibration pulses in six people

We tested a calibration method for public SEEG pulse responses in OpenNeuro ds006065 v1.0.0. It combines a shared amplitude gain with separate gains for contact pairs. The test used eight fixed-site blocks, six people, and 359 later stored segments. Each block used ten calibration pulses. We assumed nominal 500 Hz timing and targeted 50 to 250 ms. Source channel labels define the SEEG scope. Mixed gains gave 1.86% lower mean variance-scaled error than a shared gain. The person bootstrap interval was 0.51% to 3.99%. The exact two-sided person sign-flip result was p = 0.0625. A fixed half mix gave similar error. A geometry check gave an interval that includes zero. The within-pre control also gave lower error. These results do not establish a population benefit or a stimulation effect. The package preserves code, compact data, four figures, source checks, results, and reproduction instructions.

stimulation response prediction · SEEG · brain-computer interface · amplitude calibration · calibration data · intracranial EEG

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References

6
  1. usesWith 10 calibration trials, amplitude updates had lower error than waveform replacement at fixed SEEG pairs in six people sci:sha256:5fbf5699f54eed2770f2feed9404402fd27dc4a13216f041c985185e72ab0782

    Used the original source manifest and source-code audit through the direct input package. Used its fixed hippocampal pair choices only to display the eight waveform panels.

  2. usesCross-group tests did not establish SEEG response map change across six people sci:sha256:c1ee3af2654efdf1006112a9bbce8e06fd2be8451b3d580e001e611877e2e45f

    Used its upstream pair definitions and bin provenance, preserved in the direct input publication. This citation preserves the lineage of the all-pair data.

  3. usesWith 10 calibration pulses, a shared timing update had no clear benefit for late SEEG pulse predictions in six people sci:sha256:7f08802fb2748c137073279385149257362ef3e2297465527b8b1703c87b6161

    Used the complete input bins, metadata, source hashes, quality audit, and retrieval script. These files enabled the new eight-block amplitude-mix test.

  4. usesdoi:10.18112/openneuro.ds006065.v1.0.0

    The analysis uses pulse-response recordings from OpenNeuro ds006065, version 1.0.0.

  5. doi:10.1038/s41467-025-59417-7

    This is the source study describing hippocampal-network stimulation and intracranial recordings.

  6. usesdoi:10.5281/zenodo.14735080

    The upstream GPL-3.0 MATLAB archive informed documented extraction-rate, epoch, trial-count, polarity, and stimulation-site assumptions; it was not executed and is linked externally.

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