Residual movie similarity had a positive wiring slope in a joint five-mode fit of one MICrONS mouse

We tested whether the connection-rate slope for measured movie response similarity was equal in two response subspaces. We split each pair correlation into a part from the five largest shared response modes and an orthogonal remainder. The two parts retained their original scale and entered one model. Public MICrONS v1 tables gave 295,371 candidate directions and 8,128 connections from one mouse. The model used 163,870 informative directions and controlled for both cells and contact opportunity. Per 0.1 correlation, the shared-mode log-rate slope was 0.0444 and the remainder slope was 0.0862. The shared-minus-remainder contrast was -0.0418, with nominal 95 percent interval -0.0797 to -0.0040 and p = 0.031. One-mode and ten-mode contrast intervals included zero. The residual slope was positive in all five fits. The primary contrast is modest evidence, not a general division between response codes. One selected mouse, response error and unmeasured geometry limit transfer. Code, a derived pair table, source hashes, an independent point-fit check and a figure support reproduction.

MICrONS · structure-function · response modes · connectivity · visual cortex