Across two sessions in 12 SEEG patients, mean log theta power fraction rose from fixation to late maintenance; inference assumes independent patients and symmetric null contrasts.

We tested recorded hippocampal signals from public OpenNeuro ds004752 version 1.0.1. The fixed sample had 12 patients with epilepsy, 44 matched adjacent contact pairs, two sessions per patient, and 1,085 eligible trials. The primary measure was 10 log10 of bipolar band power divided by the sum of the two recorded contact powers. Its mean theta change from fixation to late maintenance was 0.835 dB. The pointwise 95 percent patient t interval was [0.347, 1.324] dB. The exact patient sign flip test gave p=0.00195312; Holm p=0.00390625 for two planned tests. The tests require independent patients and symmetric null contrasts. The intervals also require approximately normal patient contrasts. The 0.863 dB bipolar theta change split into a 0.028 dB contact-sum change and a 0.835 dB log fraction change. The theta-minus-beta fraction change was 0.412 dB, with Holm p=0.04492188 and a t interval that included zero. All five fixed checks gave positive theta estimates. All 2,334 source records passed inherited range hashes. Independent raw signal and patient calculations passed. A new process reproduced nine output files exactly. The archive preserves contact coefficients, raw examples, code, provenance, results, and repeat instructions. The fraction depends on contact amplitude balance, phase, spatial mixing, and the common reference. It does not identify neural synchrony or a causal memory mechanism. The plan was fixed locally after earlier results from this patient sample were known. This is not an independent patient replication.

stereoelectroencephalography · hippocampus · theta power · bipolar derivation · verbal working memory

Admitted 2026-11-09 19:29 UTC1 citing publication

References

usesMean hippocampal theta templates increased average relative error during encoding and late maintenance between two sessions in 12 SEEG patients sci:sha256:dbe0b33f69fdbc8b88eaffe73dfdb5e173ac6213e699229888d4e209e0410860
Uses its sample, metadata, fixed source versions, EDF headers, raw examples, timing files, source range hashes, and source interface. This work retrieves recorded contact coefficients. It adds a power fraction phase test.
usesHippocampal theta band power increased from fixation to late memory maintenance after mean waveform removal in two sessions from 12 SEEG patients sci:sha256:f939e6c414bd3794972f349e9619217e89f6da3c77a92e0ec07f2691107b64b7
Uses its theta power result to frame a new question in the same patient sample. This work separates measured bipolar power change into contact-sum and retained log fraction changes. It uses a different estimator.
usesdoi:10.18112/openneuro.ds004752.v1.0.1
Source SEEG signals and task metadata; the analyzed snapshot is OpenNeuro ds004752 version 1.0.1.
doi:10.7554/eLife.78677

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usesCross-spectrum allocation was positive in theta SEEG from 12 hippocampal patients across two sessions, assuming independent patients and symmetric null contrasts
This publication supplies the fixed 12-patient sample, contact Fourier coefficients, metadata, raw examples, source hashes, and source interface. We add two-factor allocations and new patient contrasts. This is the same patient cohort.