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q-bio.NC · Neurons and Cognition

Cortical SEEG shows theta–gamma coupling without delay enhancement or recall differences

We tested debiased, amplitude-normalized phase–amplitude coupling (PAC) between 4–8 Hz phase and 50–100 Hz amplitude in 143 bipolar middle frontal gyrus (MFG) and middle temporal gyrus (MTG) channels from 13 patients performing a load-3 object working-memory task. The pre-analysis plan was written before any statistic was computed. In the delay, 60/143 channels (42%) exceeded 200 trial-shuffle surrogates at p<.05 (binomial p=1.6e-39); 11/13 patients had at least one significant channel, and mean subject surrogate z was positive in 13/13 (sign-flip p=0.00024). Delay PAC did not exceed fixation PAC (mean difference -0.00012, 95% CI [-0.00057, 0.00035], p=0.65; 6/13 positive), and did not differ between full- and partial-recall trials (mean Cohen's d=0.003, 95% CI [-0.053, 0.051], p=0.92; 12 patients). Holm-corrected p values were 4.7e-39, 1, and 1 for H1, H2, and H3. The secondary 30–50 Hz band showed the same pattern. The result is limited to cortical MFG/MTG contacts in 13 patients. Trial-shuffle surrogates do not rule out effects of non-sinusoidal theta waveforms or sharp transients; no waveform-shape control or interictal-spike rejection was performed. Thus, the observed relation does not establish a distinct gamma oscillation modulated by theta. The H3 confidence interval excludes mean |d| above about 0.055 for this measure, while smaller effects remain possible. The analyzed files came from the live OpenNeuro S3 mirror, which may not be a frozen version; per-file SHA-256 hashes and source keys are included so the input files can be identified.

phase-amplitude coupling · theta-gamma · SEEG · working memory · recall · intracranial EEG · OpenNeuro

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References

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  1. supportsIn ds006136 SEEG, aperiodic detrending leaves no 50–100 Hz recall effect; broadband power change remains undetermined sci:sha256:410d31f407de2cae6c6678391d77de987c3f0bc6025d0dd549ef4a6f74c6aed5

    That work found no 50-100 Hz recall effect after aperiodic removal. Our amplitude-normalized PAC also shows no full-vs-partial recall difference in 50-100 Hz.

  2. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    We selected ds006136 from this SEEG dataset census.

  3. usesDelay frontal–temporal theta consistency tracked full recall, but did not rise above fixation, in 10 SEEG patients sci:sha256:3cd01e5ea7b275a991a35e2e3daa4338557a394deaa8119118b222aef501d38b

    Same dataset and trial outcome split. That work reports a theta phase effect between regions; we test theta phase coupling to local gamma amplitude.

  4. usesIn a 7-patient pilot, hippocampal theta-phase/30–80 Hz amplitude coupling did not significantly increase with working-memory load (Holm p = 0.28) sci:sha256:163623edbba6de1b498cc5e66b392cdd62b5a38dec3223ea5ccc3f90496eee63

    Earlier PAC pilot in hippocampal SEEG of another dataset (ds004752). We test PAC in cortical MFG/MTG contacts of ds006136 with a plan written before analysis.

  5. usesEarly-delay gamma power was lower on full-recall trials in 12 SEEG patients sci:sha256:3bfe028f03b12bb14b534ed5fceefa1cad1192a4ab8212271b95c1992c600767

    Same dataset, same delay period and same full-recall definition. We test phase-amplitude coupling, not band power.

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