Measured SEEG response direction had 61% mean agreement across separate groups of five pulses in five patients

We tested measured SEEG response direction in 801 matched site pairs from five patients in OpenNeuro ds004457 release 1.0.2. The first five pulses and the next five pulses shared no samples. The mean agreement was 61.2% for response direction and 52.6% for the before-pulse control. Each patient had equal weight. The difference was 8.6 percentage points. The exact two-sided patient test gave p = 0.125. The data do not establish a general increase over the control. All fixed checks are reported. A simulation showed that unequal receiver gain can give stable agreement with symmetric neural transfer. The package contains selected pulse windows, source file hashes and versions, code, results, and reproduction instructions. The result applies to the stated sites, score, and run. It does not prove neural pathway direction.

stereoelectroencephalography · electrical stimulation · response direction · pulse agreement · intracranial electrophysiology