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Four shared pulses increased correlation between five pulse SEEG averages in five patients

We tested whether shared pulses increase agreement between SEEG response averages. We used OpenNeuro ds004457 version 1.0.2, with five patients and 40 contacts selected from metadata. Both averages had five pulses. Sharing four pulses increased the mean patient correlation by 0.397 after stimulation and 0.809 before stimulation. The main analysis had 1080 site and contact pairs. All five patient effects were positive. The exact two-sided patient sign-flip p value was 0.0625. Noise-only simulations explain how overlap can create high agreement without a response. The package includes checked source hashes, pulse windows, code, results, figures, and a pulse ID audit tool. The result applies to these pulse partitions and selected contacts. It does not establish clinical reliability.

stereoelectroencephalography · SEEG · pulse overlap · waveform correlation · electrical stimulation · neuroscience · signal processing

Admitted 20 citing publications

References

3
  1. usesdoi:10.18112/openneuro.ds004457.v1.0.2

    The analysis uses OpenNeuro ds004457 version 1.0.2; its recorded metadata identifies this exact version and states CC0.

  2. doi:10.1523/JNEUROSCI.1325-22.2023
  3. doi:10.1038/nn.2303

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