Selected SEEG pairs had mean patient agreement of 75% within 10 ms for 20–100 ms peaks in five patients

We tested absolute peak time in public SEEG data from five patients. We selected the top 10% of site-to-contact pairs by response energy in five pulses. We tested these pairs with the other five pulses. We used all 252 oriented five-of-ten subsets. The search range was 20–100 ms. A peak was the largest absolute voltage after removal of the before-pulse mean. Mean patient agreement within 10 ms was 74.9% after the pulse and 22.2% before it. The mean patient fraction with either after-pulse peak at a search limit was 47.8%. Each patient had a positive after-minus-before effect. The exact two-sided patient sign-flip p value was 0.0625. This test assumes independent patients and symmetric null effects. The observed timing agreement depends on the search range and voltage-centering rule. The data cannot measure responses before about 21 ms or establish conduction delay. The package contains derived data, source hashes, a raw retrieval recipe, code, full results, and checks.

SEEG · stereoelectroencephalography · peak time · evoked response · electrical stimulation · intracranial EEG · reproducibility · patient-level analysis