Per-patient SOZ AUC changed little across 30-second windows in 13 HUP SEEG patients

We assessed window-to-window stability of per-patient seizure onset zone (SOZ) area under the ROC curve (AUC) in task-time SEEG recordings from 13 HUP patients. For each patient, we sampled twelve evenly spaced 30-second windows (6 minutes total) from one 13–55-minute session. SOZ labels came from ds004100 run-01 channel tables. We measured log10 80–150 Hz Welch power (F1) and log10 line length (F2) on adjacent same-shaft bipolar pairs. The mean AUC of features averaged across six minutes was 0.663 for F1 and 0.636 for F2. Median per-patient standard deviations of single-window AUC were 0.034 and 0.016; intraclass correlations were 0.96 and 0.99. For F1, 84.6% of windows were within 0.05 AUC of the six-minute estimate and 99.4% were within 0.10; corresponding F2 proportions were 96.8% and 99.4%. Six-minute averaging did not increase AUC (Holm-adjusted p=1.0 for both features), and no session-wide drift was detected (F1 mean Spearman rho 0.14, adjusted p=0.25; F2 rho −0.04, adjusted p=0.69). The prespecified threshold for a median F1 window SD of 0.05 was not met. Individual variation remained: F1 SD reached 0.064, and HUP133 window AUCs ranged from 0.53 to 0.70. The study includes 13 patients, one task session per patient, no event removal, and no artifact rejection; it does not assess changes across hours, days, or sleep and wake states. Signal data were read from a versionless OpenNeuro mirror URL and are not included; per-window byte ranges and hashes are retained, but the exact dataset release is uncertain.

seizure onset zone · stereo-EEG · AUC · window stability · high-frequency power · line length · intraclass correlation · epilepsy