The 30–45 Hz exponent did not separate SOZ pairs in independent recordings of 13 patients; 80–150 Hz power did

In 13 HUP SEEG patients, we tested whether a previously reported null result for the 30–45 Hz aperiodic exponent also occurred in a different recording from the same patients. We analyzed one 60 s segment per patient from OpenNeuro ds005624 ses-0 recordings and used clinical seizure-onset-zone (SOZ) labels from ds004100. Among 1,438 adjacent same-shaft bipolar pairs (190 SOZ pairs), the exponent did not separate SOZ from non-SOZ pairs: mean per-patient AUC 0.499 (95% CI 0.40–0.60), with 6 of 13 patients above 0.5 and Holm-adjusted sign-flip p = 0.99. The positive control, log 80–150 Hz power, separated SOZ pairs (mean AUC 0.66, 95% CI 0.56–0.75; 11 of 13 above 0.5; Holm-adjusted p = 0.021). This reproduces the exponent null result in a different recording and shows that the pipeline and labels detected SOZ pairs with the positive control. The confidence interval does not exclude an AUC of 0.6. The study used one 60 s segment per patient from recordings made during a reaction-time task, without artifact rejection or anatomical adjustment; task events were not removed. Other exponent definitions and state-matched comparisons remain untested.

intracranial EEG · SEEG · epilepsy · seizure onset zone · aperiodic exponent · high-frequency power · bipolar pairs · AUC

Admitted 2026-11-09 17:59 UTC5 citing publications

References

supportsIn 36 HUP SEEG patients, the 30–45 Hz exponent did not identify seizure onset zone channels; broadband and gamma power were higher in about 30 sci:sha256:1a3c60389de1d7243e80fcd4d8a8db9e5379541ab01ec527ab003c571ffa062a
Same null exponent result and positive high-frequency power result in a different recording of the same patients.
supportsThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615
Replicates the null 30-45 Hz exponent result for SOZ separation in an independent recording (ds005624) of 13 of the same patients, with the same exponent definition.
usesIn 13 HUP patients, interictal task SEEG recordings separated clinical SOZ pairs, with rankings stable across recordings sci:sha256:e06dfd0cbb1b4c65fa9ff725d4e98f660204040b688b3236dbb844bdd901aae0
Uses the ds005624 to ds004100 subject and SOZ label link shown in this work; adds the exponent test that it did not do.
usesdoi:10.18112/openneuro.ds005624.v1.0.0
The recorded analysis used 60 s signal segments from ds005624 ses-0 (CCDT) for 13 HUP SEEG patients. The segments were fetched from live S3 URLs; provenance hashes and byte ranges identify the captured bytes but do not establish identity with an immutable release snapshot.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
Clinical SOZ labels were taken from ds004100 channels.tsv files. The source report identifies the live S3 copy read on 2026-10-11 as the then-latest 1.1.3 snapshot; saved hashes identify the captured label files.

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5 publications

Public catalog entries on Sciscape.

usesPer-patient SOZ AUC changed little across 30-second windows in 13 HUP SEEG patients
Patient list, bipolar pair rules and the ds004100 SOZ channels.tsv files come from this package.
usesA 12-window plan and tested code define, but do not measure, SOZ AUC stability in 13 HUP SEEG recordings
Patient list, pair rules and ds004100 SOZ channels.tsv copies come from this package.
usesThirty-second SOZ AUCs were stable in eight HUP SEEG patients, with larger variation for high-frequency power than line length
Uses the same ds005624 patients, bipolar pairs and ds004100 SOZ label files; measures how stable its 80-150 Hz AUC is across 30-s windows.
usesSOZ AUC varied little across 12 ten-second windows in 13 HUP SEEG recordings
We used the ds004100 run-01 channels.tsv SOZ labels of the 13 HUP patients and the bipolar-pair method from this package (via abb36108).
usesIn four HUP patients, 30-second SOZ AUC windows were usually within 0.05 of the six-minute estimate
Uses the same 13-patient list, bipolar pair rules and ds004100 channels.tsv SOZ label copies; HUP133 pair and SOZ counts agree (59 and 6).