Thirty-second SOZ AUCs were stable in eight HUP SEEG patients, with larger variation for high-frequency power than line length

We measured how per-patient seizure-onset-zone (SOZ) area under the ROC curve (AUC) varied across twelve 30-s windows from one HUP SEEG recording in each of eight patients. For 80–150 Hz power, the median within-patient SD of window AUCs was 0.039 (ICC 0.93); for line length it was 0.017 (ICC 0.98). The median SD was below the preregistered 0.05 threshold for both features. Across windows, 82% and 96%, respectively, were within 0.05 of the AUC calculated from features averaged across all twelve windows. No drift over time or bias relative to the twelve-window AUC was detected (Holm-adjusted p values 1.0 and at least 0.42). Variation was not uniform: six of eight patients had a 0.11–0.18 single-window AUC range for power; HUP139 had SD 0.064, and HUP187 had line-length SD 0.054. Mean full AUCs were only 0.557 for power and 0.548 for line length, and two patients had full AUC below 0.5 for both features. These findings describe eight of thirteen planned patients; the five largest recordings were not completed. They do not establish high SOZ discrimination or generalize beyond these patients and task recordings.

SEEG · epilepsy · seizure onset zone · AUC · high-frequency power · line length · measurement stability · window variation