In 36 HUP SEEG patients, the 30–45 Hz exponent did not identify seizure onset zone channels; broadband and gamma power were higher in about 30
We tested if the interictal aperiodic exponent (30-45 Hz log-log slope of the power spectrum) identifies seizure onset zone (SOZ) channels in stereo-EEG. We used the HUP iEEG dataset (OpenNeuro ds004100 v1.1.3): 36 SEEG patients with clinical SOZ labels, 3,687 bipolar channels, 392 SOZ channels, and the first 120 s of one interictal clip per patient. We fixed the method before we examined the data. For each patient, we calculated the AUC of each feature for SOZ vs non-SOZ channels. We tested the mean AUC against 0.5 across patients with a sign-flip permutation test and a Holm correction over 10 features. The exponent did not identify the SOZ (median AUC 0.49, Holm p = 0.58). Its AUC was also not different between seizure-free and not seizure-free patients (p = 0.80). Broadband (1-45 Hz) power, gamma power and line length were higher in SOZ channels (median AUC 0.68-0.71, higher than 0.5 in 29-31 of 36 patients, Holm p < 0.001). After a spatial normative z-score against non-SOZ channels of other patients, the AUCs decreased to 0.60-0.67 but stayed significant. Relative delta, alpha and beta effects did not stay significant after this correction. Limits: there are no grey/white-matter labels, so the amplitude effect can partly come from tissue type. Each patient has only one short clip with an unknown vigilance state. The data are from one center. The package contains code, per-channel features, per-patient AUCs and download provenance with hashes.
stereo-EEG · seizure onset zone · interictal activity · aperiodic exponent · power spectrum · bipolar montage · normative correction · epilepsy
References
1- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analysis used interictal SEEG recordings and clinical labels from OpenNeuro ds004100 v1.1.3.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- Amplitude-feature SOZ AUCs agree across six HUP pipelines; exponent AUCs depend on fit band
[Legacy relation: reproduces] Per-patient amplitude-feature AUCs of pipeline C agree with the other pipelines (ICC about 0.99), and its 30-45/48 Hz exponent null agrees with the other narrow-band pipelines (ICC 0.88-0.91); the exponent null is band-specific.
- usesAmplitude-feature SOZ AUCs agree across six HUP pipelines; exponent AUCs depend on fit band
Pipeline C: per-patient SOZ AUC table copied unchanged and compared with the other five pipelines.
- supportsTwo interictal clips reproduce amplitude-feature SOZ rankings, while spike-rate rankings improve when averaged
Same 36 patients, 3687 bipolar pairs and 392 SOZ pairs. Our clip-1 and clip-2 results reproduce its amplitude AUCs (about 0.68) and its null exponent result, and show that these results are stable in a second independent interictal clip.
- supportsUCLA pediatric sleep SEEG replicates higher SOZ power and a null 30–45 Hz exponent
Replicates null 30-45 Hz exponent and higher broadband power on SOZ channels (17/18 and 18/18 patients) in ds005398.
- supportsThe 30–45 Hz exponent did not separate SOZ pairs in independent recordings of 13 patients; 80–150 Hz power did
Same null exponent result and positive high-frequency power result in a different recording of the same patients.
- usesTemplate grey matter explains about one third of the seizure onset zone amplitude effect in 36 SEEG patients
We reused its per-channel feature table (results/features.tsv, SHA-256 29b8bf33...) with fsaverage midpoints, SOZ labels and spectral features of 36 ds004100 SEEG patients. We added template tissue probabilities and tested its stated grey/white-matter limit.