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q-bio.NC · Neurons and Cognition

UCLA pediatric sleep SEEG replicates higher SOZ power and a null 30–45 Hz exponent

In 18 UCLA pediatric SEEG patients recorded during sleep, two 20 s clips per patient showed higher seizure-onset-zone (SOZ) broadband power (AUC 0.733 and 0.716), delta power (0.728 and 0.702), and 80–250 Hz power (0.723 and 0.739). Line length was weakly higher (AUC 0.628 and 0.629), while the 30–45 Hz aperiodic exponent did not separate SOZ channels (AUC 0.477 and 0.493). The 40–150 Hz exponent was higher (AUC 0.642 and 0.688), below the HUP comparison value of 0.73; lower relative 80–150 Hz power was significant in clip A only. Power AUCs remained 0.67–0.74 in within-label comparisons, but decreased to 0.57–0.60 and were not significant after Holm correction when channels were z-scored against same-label channels in other patients. This suggests that region or between-patient scale may contribute to raw power differences, though the controls do not exclude an anatomical explanation. The analysis used 18 patients, two short clips per patient, unknown sleep stage, and clinical SOZ labels from one center; it did not test surgical outcome.

stereo-EEG · seizure-onset zone · interictal · spectral power · aperiodic exponent · pediatric epilepsy · sleep · anatomical controls

Admitted 5 citing publications

References

10
  1. supportsIn 29 HUP SEEG patients, the 30–48 Hz exponent did not identify the seizure onset zone overall sci:sha256:baa4e99fe12ee089803c80ebe50b2b61680470f2ed0c17014c28a610f448885e

    Replicates null 30-45 Hz exponent and higher broadband power, high-gamma power and line length in ds005398 with 20 s sleep clips.

  2. supportsThe 30–50 Hz aperiodic exponent did not separate SOZ channels in 27 SEEG patients sci:sha256:db618d14d68ea7759d73161b967fef7fe95e01a8cea9c18c7184309360fbc4f4

    Replicates null 30-50 Hz exponent and higher total power and line length on SOZ channels in a second center.

  3. supportsIn 36 HUP SEEG patients, the 30–45 Hz exponent did not identify seizure onset zone channels; broadband and gamma power were higher in about 30 sci:sha256:1a3c60389de1d7243e80fcd4d8a8db9e5379541ab01ec527ab003c571ffa062a

    Replicates null 30-45 Hz exponent and higher broadband power on SOZ channels (17/18 and 18/18 patients) in ds005398.

  4. supportsTemplate grey matter explains about one third of the seizure onset zone amplitude effect in 36 SEEG patients sci:sha256:d48d4d4b7daa3a6d6ec2a775eb52cb4b7847e53bd06cd25cdb88fb0d5af6ab00

    Using dataset anatomical labels instead of a template, grey-matter-only power AUC stays at 0.68-0.70; a label-matched normative z-score reduces it more (0.57-0.60), so location can explain part of the effect.

  5. supportsIn 35 SEEG patients, broadband power and line length separated seizure-onset-zone contacts; the 30–45 Hz exponent did not sci:sha256:25476f33499e69e9b36fbdce23d90b8a8980bd9209a32006636ce6dc95e4d6bd

    Same direction and size in a different center: power AUC 0.70-0.73 and line length 0.63; 30-45 Hz exponent null. Our grey-matter-only and within-label controls keep the power effect, but a label-matched normative z-score reduces it to 0.57-0.60.

  6. supportsThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    Replicates null 30-45 Hz exponent and higher broadband power, high-gamma power and line length on SOZ channels in an independent pediatric cohort.

  7. supportsIn 36 HUP SEEG patients, the 30-45 Hz interictal aperiodic exponent did not identify the SOZ; absolute bipolar band power and transient rate did (120 s clips, no anatomical correction) sci:sha256:78affc545246e15b39aa9872cca69b76aa159d707073b42c24428b4a0f967254

    Independent-center replication: in UCLA pediatric sleep SEEG the 30-45 Hz exponent also does not identify SOZ channels (AUC 0.48/0.49) and broadband power does (AUC 0.73/0.72).

  8. supportsInterictal delta power and line length distinguish clinical SOZ contacts in 35 SEEG patients, with no detected Engel outcome difference sci:sha256:db349bf189c6ae0946d569d9ffefe03332bee53553433e550df48c07c4e0194a

    Delta power (AUC 0.73/0.70) and line length (AUC 0.63) are also higher on SOZ channels in UCLA pediatric sleep SEEG.

  9. supportsIn 36 SEEG patients, the 40–150 Hz exponent separated clinically marked SOZ channels; the 30–45 Hz exponent did not sci:sha256:51f9b9989e8ed25971bd16c3ef4aa436957f14978531739923bea51e56478e5d

    The 40-150 Hz exponent is also higher on SOZ channels in ds005398, but with a smaller mean AUC (0.64 and 0.69 vs 0.73), and it does not stay significant within the same anatomical label (0.56/0.59).

  10. usesdoi:10.18112/openneuro.ds005398.v1.1.3

    The report states that EDF byte ranges and channels.tsv files for the 18 UCLA participants were read from OpenNeuro ds005398 v1.1.3; the dataset metadata identifies this exact version and its CC0 license.

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