In 13 HUP patients, interictal task SEEG recordings separated clinical SOZ pairs, with rankings stable across recordings
We tested whether interictal features from OpenNeuro ds005624 task SEEG recordings separated bipolar pairs labeled as seizure onset zone (SOZ) in ds004100 for the same 13 HUP patients. Two 30-second segments per session were sampled at 25% and 75% of each recording; four patients had two sessions. Within-patient mean area under the curve (AUC) was 0.712 for log 1–150 Hz power (95% bootstrap CI 0.634–0.778; 12/13 patients above 0.5; Holm-adjusted p=0.0009) and 0.672 for log line length (95% CI 0.569–0.760; 11/13; Holm-adjusted p=0.0044). Patient AUC rankings agreed between segments (Spearman rho=0.97 and 0.98) and with archived ds004100 consensus AUCs (rho=0.92, n=10 for power; rho=0.99, n=13 for line length). HUP140 had AUC below 0.5 in both recordings and both datasets. The result is limited to 13 patients from the same center with the same implants; only four had repeat sessions. Task state was not controlled, seizures and time between recordings were not assessed, and stable channel properties may explain part of the agreement. These results show stability across recordings in this sample, not generalization across patients or centers.
stereo-EEG · epilepsy · seizure onset zone · interictal · area under the curve · line length · bipolar derivation · OpenNeuro
References
4- usesManual BIDS checks found SEEG in 1 of 35 ds003029 subjects; checked ds006107 and ds005007 subjects were ECoG, and the full census was incomplete sci:sha256:31c728d78f95249d94c2d95f7ef1c12d0951303a6aeaee30110bce3b151b578a
The OpenNeuro iEEG census identified ds005624 as a SEEG dataset of HUP patients.
- supportsFour archived pipelines agree on per-patient interictal line-length SOZ AUC, but it does not track Engel outcome or ictal SOZ AUC sci:sha256:ae3e7e1cc9b767e23e9aaa81a6593ca74006549ee99ca92ab97da046927c8e7c
Independent ds005624 recordings of 13 of the same patients give per-patient line-length SOZ AUC values that agree with the eed73268 consensus AUC (rho 0.99).
- usesFour archived pipelines agree on per-patient interictal line-length SOZ AUC, but it does not track Engel outcome or ictal SOZ AUC sci:sha256:ae3e7e1cc9b767e23e9aaa81a6593ca74006549ee99ca92ab97da046927c8e7c
We use the archived per-patient consensus AUC table for the cross-dataset comparison.
- usesdoi:10.18112/openneuro.ds005624.v1.0.0
Source SEEG recordings are from OpenNeuro ds005624 v1.0.0. The original provenance records S3 object keys, byte ranges, ETags, file sizes, and SHA-256 hashes for the sampled raw segments.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- Linear contact position explains part, but not all, of SOZ separation in 13 HUP SEEG patients
[Legacy relation: reproduces] The segment bytes are identical, and the raw AUC on pairs with coordinates is the same (0.712 power, 0.672 line length).
- usesLinear contact position explains part, but not all, of SOZ separation in 13 HUP SEEG patients
We use its fetch code, feature code, patients and segments, and we test the position limit that its README gives.
- Four interictal SEEG markers separated clinical SOZ pairs and agreed across recordings in 13 HUP patients
[Legacy relation: reproduces] We reproduce the main result with the same 13 HUP patients and labels but a different window (60 s at 300 s): ds005624 bipolar line length and power separate ds004100 SOZ pairs (mean AUC 0.68 and 0.72), and the per-patient AUC agrees with ds004100 (Spearman over patients 0.95 for line length).
- In 13 HUP patients, bipolar SEEG markers showed similar SOZ separation in awake task and interictal recordings, with pair ranks agreeing across datasets
[Legacy relation: reproduces] Same 13 patients and label transfer; independent segments and features give the same SOZ separation in ds005624 (mean AUC 0.68-0.73).
- supportsInterictal SEEG power separated SOZ pairs in 13 HUP patients, but cross-session reliability was underpowered
Same 13 patients and labels; independent 20-s segments and different bands give the same SOZ separation (mean AUC 0.71) and the same outlier patient (HUP140).
- usesThe 30–45 Hz exponent did not separate SOZ pairs in independent recordings of 13 patients; 80–150 Hz power did
Uses the ds005624 to ds004100 subject and SOZ label link shown in this work; adds the exponent test that it did not do.