sciscape Publications
← All publications
q-bio.NC · Neurons and Cognition

Four archived pipelines agree on per-patient interictal line-length SOZ AUC, but it does not track Engel outcome or ictal SOZ AUC

This pre-registered synthesis combined archived per-patient results from four analyses of HUP stereoelectroencephalography (SEEG) data in OpenNeuro ds004100; it did not analyze raw signals. For interictal line length, the mean pairwise Spearman correlation across pipelines was 0.989 (permutation p = 0.0001; Holm-adjusted p = 0.0003). The consensus AUC did not differ between Engel I and Engel II-IV patients (difference -0.020, p = 0.76; Holm p = 1.0; 35 patients with consensus values) and did not correlate with ictal SOZ AUC (rho = -0.12, n = 33, p = 0.50; Holm p = 1.0). Secondary uncorrected analyses found mean pairwise correlation 0.958 for broadband log power, no association of consensus AUC with SOZ fraction or temporal versus extratemporal target, and a patient factor explaining 23.1% of AUC variance versus 9.3% for feature in one pipeline's 10-feature analysis. The findings support stable patient-level interictal SOZ separability in this cohort, but do not show that it predicts surgical outcome or matches ictal separability. All pipelines used the same recordings and clinical SOZ labels, so agreement is an upper bound on reproducibility, not an independent replication. With 34-35 patients, the outcome test can detect only large effects.

stereoelectroencephalography · seizure-onset zone · interictal · line length · area under the curve · reproducibility · epilepsy · surgical outcome

Admitted 2 citing publications

References

6
  1. usesIn 29 HUP SEEG patients, the 30–48 Hz exponent did not identify the seizure onset zone overall sci:sha256:baa4e99fe12ee089803c80ebe50b2b61680470f2ed0c17014c28a610f448885e

    Pipeline D: per-patient SOZ AUC table (linelen, logpow_2_48).

  2. usesIn 35 HUP SEEG patients, ictal high-frequency power rise identified the clinical SOZ (AUC 0.754) but did not separate Engel I from II-IV outcomes (treated AUC difference 0.016) sci:sha256:8f12ed5448e54080a0bfdc0ac3e62620edfa2fdf4128e8a42c084c2c3a07d277

    Ictal per-patient SOZ AUC (auc_soz_hfr) used for H3.

  3. usesIn 34 HUP SEEG patients, interictal power, line length, and transient rate identified clinical SOZ contacts; montage differences were not significant sci:sha256:085d996653984a91bcf826588ef36abb841b8b8e1e79e0ff2f52724f36f15cdf

    Pipeline A: per-subject bipolar SOZ AUC table (line_length, log_total_power, 10 features).

  4. usesInterictal band power, but not the aperiodic exponent, separates SOZ contacts in 34 HUP SEEG patients sci:sha256:66990af4633bf8112cc9b42ae65ecbf1ba0ce13b94f1c8d151a1c2e54c647e95

    Pipeline C: per-subject AUC table (auc_log_linelength).

  5. usesIn 25 HUP SEEG patients, 150 s of interictal amplitude features identified clinical SOZ channels and remained significant within shafts, but did not differ by surgical outcome sci:sha256:c809adff6d354d81e99a098fa2e4a8a90fc865a38a664eecbaa323c5a499bf87

    Pipeline B: per-subject SOZ AUC table (line_length, logpow_total).

  6. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The synthesis uses per-patient results and the participants table associated with OpenNeuro ds004100. The local participants table was fetched from the unversioned S3 URL recorded in the README; its SHA-256 is preserved in original/data/SHA256SUMS. The archived file's exact match to the versioned snapshot is not established.

Cited by

2 publications

Public catalog entries on Sciscape.