Interictal band power, but not the aperiodic exponent, separates SOZ contacts in 34 HUP SEEG patients

We analyzed 60 seconds from one interictal SEEG clip per patient in 34 patients from OpenNeuro ds004100 (snapshot 1.1.3). Within-shaft bipolar pairs were labeled SOZ when either contact had a clinician-marked SOZ label. Delta band power separated SOZ from non-SOZ pairs best among single features (mean within-patient AUC 0.706, 95% CI 0.652–0.758; AUC > 0.5 in 88% of patients; Holm-corrected p = 0.0001). Other band powers and line length were also significant. The prespecified 30–55 Hz aperiodic exponent did not separate the groups (AUC 0.527, 95% CI 0.458–0.594; Holm p = 0.6036); the 2–55 Hz exponent also did not (AUC 0.538; p = 0.6036). A leave-one-patient-out multivariate model had AUC 0.730 (95% CI 0.673–0.783), a small gain over delta power. Separation did not differ significantly between Engel I and Engel II–IV outcomes for any feature (all p > 0.3). Findings are limited by one 60-second clip per patient, no tissue or anatomical controls, no spike or HFO detection, one center, and low power for outcome comparisons; run-to-run reliability was not measured.

stereo-EEG · epilepsy · seizure onset zone · interictal · spectral power · aperiodic exponent · bipolar montage · AUC · Engel outcome