In 13 HUP patients, bipolar SEEG markers showed similar SOZ separation in awake task and interictal recordings, with pair ranks agreeing across datasets

We compared bipolar stereo-EEG (SEEG) amplitude markers in two public datasets for the 13 HUP patients present in both: OpenNeuro ds005624 v1.0.0, which contains awake Color Change Detection Task recordings, and ds004100 v1.1.3, which contains clinical interictal recordings and seizure-onset-zone (SOZ) labels. Labels from ds004100 were transferred by channel name. Using the same analysis code on both datasets, delta power (1–4 Hz), broad power (1–45 Hz), and line length separated SOZ from other bipolar pairs in the task data (mean AUC 0.733, 0.724, and 0.681; Holm-adjusted p = 0.0011, 0.0011, and 0.0044). Paired task-minus-interictal AUC differences were −0.017 (95% CI −0.043 to 0.010), −0.003 (−0.028 to 0.023), and +0.008 (−0.013 to 0.028), respectively; none was significant. Pair-value ranks agreed strongly between datasets (mean Spearman rho 0.95–0.97 across features; sign-flip p = 0.00012). Exploratory comparisons found a larger task AUC for beta power (+0.037, Holm-adjusted p = 0.014 across eight bands); gamma did not remain significant after that correction. These findings apply to one center and 13 patients with the same implants and labels. Fixed contact properties may explain much of the rank agreement; recording interval, sleep or wake state of the interictal clips, and task timing are unknown.

stereo-EEG · epilepsy · seizure-onset zone · signal features · intracranial EEG · OpenNeuro · AUC · rank agreement