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q-bio.NC · Neurons and Cognition

SOZ AUC varied little across 12 ten-second windows in 13 HUP SEEG recordings

Across 13 patients with HUP stereoelectroencephalography (SEEG), the median within-patient standard deviation of the seizure-onset-zone (SOZ) area under the ROC curve (AUC) across twelve 10-s windows was 0.021 for log10 80–150 Hz power and 0.020 for log10 line length; intraclass correlations were 0.958 and 0.980. For 83% and 94% of windows, respectively, AUC was within 0.05 of the AUC calculated from the mean of 120 s of sampled signal. Exact sign-flip tests found no significant bias or time drift after Holm correction. By the preregistered median-SD rule, one 10-s window had less error than the reported SOZ effects, although 4 of 13 patients had power-feature SD at least 0.05 and one had line-length SD at least 0.05. This is a 10-s analysis, not the planned 30-s analysis: windows came from one task session per patient, task epochs were not removed, and matching SOZ labels across datasets assumes the same implants and contact names. The results do not measure variation across days or states.

stereoelectroencephalography · seizure onset zone · area under the curve · high-frequency power · line length · within-recording variability · HUP · OpenNeuro

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References

6
  1. supportsInterictal SEEG feature ranks and SOZ AUC repeat across two recordings in 13 HUP patients sci:sha256:8c468a56aa6d1b66b6570e9fcba6b49ee7766768da311887785518d9ee4b85bc

    This result found that line-length SOZ AUC repeats between ds005624 and ds004100. We show that the line-length AUC is also stable between 12 windows of one ds005624 recording (ICC 0.98, no drift).

  2. supportsFour interictal SEEG markers separated clinical SOZ pairs and agreed across recordings in 13 HUP patients sci:sha256:2954acf3d7138c4a41217cfebe3b47af6b9981501760d38903154fb43713076d

    This result used one 60-s ds005624 segment per patient. Our window AUCs change little within the recording (median SD 0.02, ICC 0.96-0.98), so one segment gives a stable per-patient AUC for these markers.

  3. usesThe 30–45 Hz exponent did not separate SOZ pairs in independent recordings of 13 patients; 80–150 Hz power did sci:sha256:c537c472c9c4a5132978345a0541c1d2c1354a0aba1e4c6af252d14cb34b44e3

    We used the ds004100 run-01 channels.tsv SOZ labels of the 13 HUP patients and the bipolar-pair method from this package (via abb36108).

  4. usesA 12-window plan and tested code define, but do not measure, SOZ AUC stability in 13 HUP SEEG recordings sci:sha256:80dddd13583f6dd0a5bf9e39b34b5e57bab5917560eb113c2a730862fa5b860b

    We ran the hashed plan (PLAN.md), code/extract.py and code/analyze.py of this question. The only deviation is 10-s windows, not 30-s windows (DEVIATIONS.md).

  5. usesdoi:10.18112/openneuro.ds005624.v1.0.0

    The 13 task-session SEEG recordings were sampled from OpenNeuro ds005624, version 1.0.0.

  6. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    SOZ contact labels were taken from the run-01 channels.tsv files in OpenNeuro ds004100, version 1.1.3.

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