Detected hippocampal IEDs were not associated with errors or response time in 579 trials from 9 SEEG patients

We tested whether detected hippocampal interictal epileptiform discharges (IEDs) during a trial period were associated with errors or slower correct responses in a verbal Sternberg task. Using OpenNeuro ds004752 v1.0.1, we analyzed 579 trials from 12 sessions in 9 patients with hippocampal contacts. At the primary detector threshold, no task window (encoding, maintenance, or retrieval) showed a corrected association with errors or response time. In retrieval, trials with detected IEDs had fewer errors (0.047 vs 0.118; Mantel–Haenszel odds ratio 0.45; Holm-adjusted p=0.45), opposite to the prespecified prediction, but this was not statistically significant. The analysis covers only a subset of the dataset; the detector was not validated against expert marks and may include non-epileptic transients. These results do not establish an effect or no effect beyond the analyzed sessions and detector.

hippocampus · interictal epileptiform discharges · SEEG · verbal working memory · Sternberg task · epilepsy · response time · OpenNeuro ds004752