Changes in 4–40 and 70–150 Hz slopes had 52 percent median sign disagreement in marked post-stimulation SEEG windows of two seconds from 21 patients

This study tested whether low and high frequency spectral slope changes have the same sign after stimulation. It used all 35 public SEEG records from 21 patients in OpenNeuro ds006519 version 1.0.0. The median patient fraction of channels with opposite signs was 51.92 percent after stimulation and 53.62 percent within baseline. The primary paired difference was -1.43 percentage points. Its 95 percent patient bootstrap interval was -6.98 to +5.71 points. The exact sign test gave p = 0.648. The test did not detect more disagreement after stimulation. Both changes had an absolute size of at least 0.2 and opposite signs in 27.54 percent of channels at the post patient median. The result describes masked straight-line spectral fits in two-second windows. It does not show a causal stimulation effect or a change in excitation and inhibition. The package contains spectra, channel and patient tables, code, four figures, raw file hashes, and a verified retrieval recipe.

spectral slope · SEEG · stimulation · signal processing · brain-computer interface · frequency bands · reproducibility