With a common average reference, gamma power change had lower mean onset label AUC than pre-onset power within contact name groups in 30 SEEG patients

We tested whether early gamma power change improved the rank of clinical seizure onset zone labels. We used public SEEG data from OpenNeuro ds004100 version 1.1.3. The primary comparison used 30 patients, two selected seizures each, and mixed-label contact name groups. Scores used a common average reference and a fixed positive direction. The band was 30 to 80 Hz, with 55 to 65 Hz omitted. The baseline was 20 to 10 seconds before onset. The seizure window was the first 10 seconds. Mean label AUC was 0.647 for change and 0.806 for baseline power. The paired difference was -0.159, with a 95% patient bootstrap interval of -0.255 to -0.066. The exact sign-flip p value was 0.00245 under assumptions of independent patients and null sign symmetry. The all-contact comparison had an interval that included zero. The result concerns these fixed rankings and does not establish a clinical rule. All 62 raw windows passed an independent signal check. The package preserves code, data, metadata, pinned retrieval recipes, results, and reproduction instructions.

seizure onset zone · stereoelectroencephalography · gamma power · intracranial EEG · area under the curve · baseline normalization · epilepsy