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q-bio.NC · Neurons and Cognition

The early CCEP N1 did not decrease across five pulses at 5 s intervals in eight SEEG patients

We tested whether the early cortico-cortical evoked potential (CCEP) N1 (10–50 ms) decreased from pulse 1 to pulses 2–5 during clinical single-pulse electrical stimulation. We joined the archived single-trial N1 table to pulse metadata reconstructed from OpenNeuro ds005448 v1.0.0 for 8 SEEG patients, 10 selected pairs per patient, and recording channels at least 10 mm from the stimulated pair. Across 2,540 real blocks, the patient-mean pulse-1-minus-pulses-2–5 difference was −0.033 within-block SD (95% t-CI −0.145 to 0.079; exact sign-flip p = 0.50; site-permutation p = 0.43). The Spearman correlation of N1 score with pulse number was +0.024 (sign-flip p = 0.28; site-permutation p = 0.16). Sham windows showed no pulse-number trend. A positive control found a 0.87 within-direction SD higher score at 2 mA than at 1 mA in sub-STREEF07, supporting the pulse join and sensitivity to dose. Under the tested conditions (5 pulses, 5 s intervals, 1–2 mA), the N1 did not decrease with pulse number; the 95% interval excludes a decrease larger than 0.08 within-block SD. Pulse 1 followed a longer interval (median about 11.7 s), so the pulse-1 comparison mixes pulse number and interval. The analysis used relative z scores, not microvolts, and does not establish results for longer trains, higher rates, across-block habituation, or later CCEP components.

cortico-cortical evoked potentials · N1 · habituation · single-pulse electrical stimulation · SEEG · intracranial EEG · pulse train · brain-computer interface

Admitted 2 citing publications

References

5
  1. usesPre-pulse 4–20 Hz phase did not predict CCEP N1 amplitude in 8 SEEG patients sci:sha256:65c60c58375bbd719b8dc38c3d1e55ff74b64e402df147586b75a6717f8a37f1

    Source of the single-trial N1 table and of the archived events files used to rebuild pulse order.

  2. usesIn 8 SEEG patients, 6–15 Hz pre-stimulus magnitude weakly predicted CCEP N1, but magnitude-weighted phase did not sci:sha256:991a169dbdc040cfe08228ddff01c2e105ead8aaa2d7b4bf1b56f7f16f698910

    Copy of the same single-trial table; checksum matches.

  3. supportsAt one usable SEEG site, a one-pulse map agreed with a six-pulse map, but CCEP amplitude showed no monotonic change sci:sha256:f038e9810fc78b98ec864c16b4c9881adb8f76c5c40798e4158f063cc8fb521a

    That result found no pulse-number trend at one site in ds004977. This result finds the same in 8 patients and 80 stimulated pairs in ds005448.

  4. supportsDoubling current increased early CCEP amplitudes about twofold while preserving most of the map in two SEEG patients sci:sha256:6206917cfc7dbdab7a49b6286818f166902ae25e79a8f4f54f0d1ed746e72293

    Our positive control (sub-STREEF07, 2 mA against 1 mA blocks) also shows a larger N1 at 2 mA.

  5. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    Source dataset (STReEF), version 1.0.0; the archived events and channel metadata were used to reconstruct pulse order and stimulation conditions for the analyzed N1 table.

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