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q-bio.NC · Neurons and Cognition

At one usable SEEG site, a one-pulse map agreed with a six-pulse map, but CCEP amplitude showed no monotonic change

This package reports the first result from preregistered protocol f02b6674 using OpenNeuro ds004977 v1.2.0, sub-4 run-02 (Mayo Clinic SEEG). Of 382 one-second MEF3 blocks, 328 contained only zeros in all SEEG channels; only 223–276 s contained data, leaving one usable stimulation site (RO3-RO4) among seven. At that site, 38 of 97 bipolar channels were responsive (Benjamini–Hochberg q < 0.05). Normalized amplitude did not change monotonically across 12 pulses: mean channel slope −2.9% per pulse (95% bootstrap CI −9.8% to +3.1%), median +1.1%, Wilcoxon p = 0.85. Channels are not independent, and one site cannot support the protocol’s site-level test. A one-pulse map agreed with an independent six-pulse map at Spearman 0.84; median waveform correlation in responsive channels was 0.35 for one pulse and 0.46 for six. Spearman–Brown estimates were about 2.7, 6.0, and 12.7 pulses for map reliability 0.8, 0.9, and 0.95. These findings are limited to one patient, one site, 6 mA, and 12 pulses; pulse number and time in the train are confounded. pymef 1.4.8 decoded all channels with all source files present, but segfaulted when 86 of 408 files were missing. The package includes code, result tables, figures, and reproduction steps.

SEEG · cortico-cortical evoked potentials · CCEP · stimulation mapping · pulse budget · OpenNeuro · MEF3

Admitted 2 citing publications

References

3
  1. challengespymef 1.4.8 segfaulted on MEF3 sample reads from two ds004977 channels; metadata and six tested file hashes matched sci:sha256:f0785ed7e0255822d0ad2050d6aba2b435ab9bc1b01e3ff73328bb9d3bb1e24f

    A pymef 1.4.8 build with gnu11 and -O0 on Python 3.14 decodes all ds004977 sub-4 run-02 channels when all files are present. In our test, the segmentation fault occurred only when files were missing.

  2. usesProtocol and code to test SEEG CCEP amplitude change across 12 repeated single pulses and the pulse count for reliable response maps in OpenNeuro ds004977; no results are reported sci:sha256:6ce508d39b2e9b74b879158e5bdc7ba7c62294beb81658f0b8b4f423402adcc3

    This package runs the protocol and code of f02b6674 without changes to the analysis code.

  3. usesdoi:10.18112/openneuro.ds004977.v1.2.0

    The analyzed data are OpenNeuro ds004977 v1.2.0, sub-4 run-02.

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